Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/45495
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dc.contributor.authorVazquez-Huerta, D.I.
dc.contributor.authorAlvarez-Rodriguez, B.A.
dc.contributor.authorTopete-Reyes, J.F.
dc.contributor.authorMunoz-Valle, J.F.
dc.contributor.authorParra-Michel, R.
dc.contributor.authorFuentes-Ramirez, F.
dc.contributor.authorSalazar-Lopez, M.A.
dc.contributor.authorValle, Y.
dc.contributor.authorReyes-Castillo, Z.
dc.contributor.authorCruz-Gonzalez, A.
dc.contributor.authorBrennan-Bourdon, L.M.
dc.contributor.authorTorres-Carrillo, N.
dc.date.accessioned2015-09-15T19:14:29Z-
dc.date.available2015-09-15T19:14:29Z-
dc.date.issued2014
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84907215523&partnerID=40&md5=035ea9445f66e637c0d7b8da9b80f0c8
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25232395
dc.identifier.urihttp://hdl.handle.net/20.500.12104/45495-
dc.description.abstractChronic kidney disease (CKD) is characterized by accumulation of proinflammatory cytokines, mainly tumor necrosis factor alpha (TNF-?). Single nucleotide polymorphisms (SNPs) of TNFA gene, including -238 G/A and -308 G/A, have been associated with alteration in the soluble TNF-? (sTNF-?) expression. The aim was to investigate the association of -238 y -308 TNFA gene SNPs with sTNF-? levels in CKD patients. We included 150 CKD patients and 192 control subjects (CS). Both SNPs were genotyped with polymerase chain reaction-restriction fragment length polymorphism technique and sTNF-? levels were measured by enzyme-linked immunosorbent assay. The genotypic distribution of -238 and -308 SNPs was not significantly different between CKD patients and CS (p > 0.001). However, the sTNF-? levels were higher in CKD, compared to CS (p < 0.001). Also, sTNF-? correlated with creatinine (r = 0.279, p = 0.004), urea (r = 0.325, p = 0.001), phosphorus (r = 0.479, p = 0.001), glomerular filtration rate (r = -0.236, p = 0.019) and monocyte count (r = 0.276, p = 0.010). In conclusion, elevated sTNF-? levels are associated with CKD. However, the -238 and -308 TNFA gene SNPs were not associated with susceptibility to CKD and sTNF-? levels in a Mexican population. � 2014, E-Century Publishing Corporation. All rights reserved.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyMEDLINE
dc.relation.isreferencedbyWOS
dc.titleTumor necrosis factor alpha -238 G/A and -308 G/A polymorphisms and soluble TNF-? levels in chronic kidney disease: Correlation with clinical variables
dc.typeArticle
dc.relation.ispartofjournalInternational Journal of Clinical and Experimental Medicine
dc.relation.ispartofvolume7
dc.relation.ispartofissue8
dc.relation.ispartofpage2111
dc.relation.ispartofpage2119
dc.subject.keywordCKD; TNF-? levels; TNFA polymorphisms
dc.contributor.affiliationV�zquez-Huerta, D.I., Instituto de Investigaci�n en Ciencias Biom�dicas (IICB), Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico; Alvarez-Rodr�guez, B.A., Departamento de Biolog�a Molecular y Gen�mica, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico; Topete-Reyes, J.F., Servicio de Nefrolog�a, Hospital General Regional No. 46, Instituto Mexicano del Seguro SocialGuadalajara, Jalisco, Mexico; Mu�oz-Valle, J.F., Instituto de Investigaci�n en Ciencias Biom�dicas (IICB), Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico; Parra-Michel, R., Servicio de Nefrolog�a, Hospital General Regional No. 46, Instituto Mexicano del Seguro SocialGuadalajara, Jalisco, Mexico; Fuentes-Ram�rez, F., Servicio de Nefrolog�a, Hospital General Regional No. 46, Instituto Mexicano del Seguro SocialGuadalajara, Jalisco, Mexico; Salazar-L�pez, M.A., Servicio de Nefrolog�a, Hospital General Regional No. 46, Instituto Mexicano del Seguro SocialGuadalajara, Jalisco, Mexico; Valle, Y., Instituto de Investigaci�n en Ciencias Biom�dicas (IICB), Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico; Reyes-Castillo, Z., Instituto de Investigaci�n en Ciencias Biom�dicas (IICB), Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico; Cruz-Gonz�lez, A., Instituto de Investigaci�n en Ciencias Biom�dicas (IICB), Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico; Brennan-Bourdon, L.M., Instituto de Investigaci�n en Ciencias Biom�dicas (IICB), Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico; Torres-Carrillo, N., Instituto de Investigaci�n en Ciencias Biom�dicas (IICB), Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico
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