Please use this identifier to cite or link to this item:
|Title:||The genus Disciphania (Menispermaceae: Tinosporoideae, Tinosporeae) in Mexico|
|Abstract:||The influence of genetic factors in rheumatoid arthritis (RA) has been described, including several cytokine genes such as transforming growth factor ? (TGF-?) with regulatory effects on lymphocytes, dendritic cells, macrophages, chondrocytes, and osteoblasts, which are important in the RA pathogenesis. The G915C TGF-?1 polymorphism has been associated with soluble TGF-?1 (sTGF-?) serum levels. Thus, we studied the association of G915C (Arg25Pro) TGF-?1 polymorphism with sTGF-?1 serum levels in RA. We enrolled 120 RA patients and 120 control subjects (CS). The G915C TGF-?1 polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, and sTGF-?1 serum levels were quantified using an ELISA kit. The genotype frequency of G915C TGF-?1 polymorphism in RA and CS was G/G (91.7%), G/C (8.3%), C/C (0%) and G/G (85.8%), G/C (14.2%), C/C (0%), respectively, without significant differences. Moreover, the G/G TGF-?1 genotype carriers presented the highest disability index evaluated for the Spanish HAQ-DI score (P < 0.001). In addition, the sTGF-?1 serum levels were higher in RA (182.2 ng/mL) than CS (160.2 ng/mL), there was not significant difference. However, we found a positive correlation between the sTGF-?1 serum levels and the functional class (r = 0.472, P = 0.023). In conclusion, the G915C (Arg25Pro) TGF-?1 polymorphism is not associated with RA, but the sTGF-?1 serum levels are related with the functional class in RA. " 2010 Springer-Verlag.",,,,,,"10.1007/s00296-010-1624-x",,,"http://hdl.handle.net/20.500.12104/45128","http://www.scopus.com/inward/record.url?eid=2-s2.0-84857060603&partnerID=40&md5=e16fd3a5692ac9b9038e847484a4f720|
MEDLINE",,,,"Index Medicus;Adolescent;Adult;Aged;Aged, 80 and over;Amino Acid Substitution/ge [Genetics];Arthritis, Rheumatoid/cl [Classification];Arthritis, Rheumatoid/eh [Ethnology];Arthritis, Rheumatoid/ge [Genetics];Female;Genotype;Humans;Male;Mexico/eh [Ethnology];Middle Aged;Polymorphism, Single Nucleotide/ge [Genetics];Transforming Growth Factor beta1/bl [Blood];Transforming Growth Factor beta1/cl [Classification];Transforming Growth Factor beta1/ge [Genetics];Young Adult",,"Functional class; Polymorphism; Rheumatoid arthritis; TGF-?1",,,,,,"The functional class evaluated in rheumatoid arthritis is associated with soluble TGF-?1 serum levels but not with G915C (Arg25Pro) TGF-?1 polymorphism",,"Article" "46913","123456789/35008",,"Carrillo-Reyes, P., Centro de Investigaciones en Ecosistemas, Universidad Nacional Autónoma de México, Antigua carretera a Patzcuaro 8701.Col. Ex-Hacienda de San, 58190 Morelia, Michoacán, Mexico, Herbario Luz María Villarreal de Puga (IBUG), Instituto de Botánica, Universidad de Guadalajara, Km 15.5 carretera a Nogales, Predio Las Agujas, 45110 Zapopan, Jalisco, Mexico; Sahagún-Godínez, E., Jardín Botúnico y Herbario, Universidad Autónoma de Guadalajara, Apartado postal 1-440, 44100 Guadalajara, Jalisco, Mexico; Ibarra-Manríquez, G., Centro de Investigaciones en Ecosistemas, Universidad Nacional Autónoma de México, Antigua carretera a Patzcuaro 8701.Col. Ex-Hacienda de San, 58190 Morelia, Michoacán, Mexico",,"Carrillo-Reyes, P.
Ibarra-Manriquez, G.",,"2013",,"A revision is presented for the four Mexican species of the genus Disciphania: D. cardiophylla, D. caloparpa, D. mexicana, and D. spadicea. The latter represents a new record for Mexico, while D. mexicana is reported for the first time in the Mexican states of Michoacán and Sinaloa. Additionally, we report the occurrence of the monoecious condition in D. spadicea, which represents the first report of this phenomenon for the genus. A key to identify the species, descriptions, illustrations, distribution maps, and assessments of the conservation status based on the IUCN criteria are provided. " 2013 The New York Botanical Garden.
|Appears in Collections:||Producción científica UdeG|
Files in This Item:
There are no files associated with this item.
Items in RIUdeG are protected by copyright, with all rights reserved, unless otherwise indicated.