Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/44756
Title: Structural and functional characteristics of glutamate transporters: How they are related to epilepsy and oxidative stress [Características estructurales y funcionales de los transportadores de glutamato: Su relación con la epilepsia y el estrés oxidativo]
Author: Hernandez-Gutierrez, S.
Hernandez-Franco, P.
Martinez-Tripp, S.
Ramos-Kuri, M.
Rangel-Villalobos, H.
Issue Date: 2005
Abstract: A Mexican population sample was obtained from the central region of the country, including five states. Two hundred and eleven individuals were PCR-typed for 15 STR loci with the AmpF? STR Identifiler PCR amplification kit (Applied Biosystems). The following autosomal markers were analyzed: D8S1179, D21S11, D7S820, CSF1PO, D19S433, vWA, TPOX, D18S51, D3S1358, TH01, D13S317, D16S539, D2S1338, D5S818, FGA and Amelogenin. Allele frequencies for each STR were estimated and compared to previous reports. Genotype distribution by locus and by two loci combination was in agreement with Hardy-Weinberg expectations for all 15 STRs. This STR system in Mexican-mestizos presented a combined probability of exclusion (PE) and discrimination (PD) longer than 99.999%. " 2004 Elsevier Ireland Ltd. All rights reserved.",,,,,,"10.1016/j.forsciint.2004.09.080",,,"http://hdl.handle.net/20.500.12104/44756","http://www.scopus.com/inward/record.url?eid=2-s2.0-20444413468&partnerID=40&md5=6792565888637cd50dd9401461114355",,,,,,"1",,"Forensic Science International",,"97
100",,"151",,"Scopus
WOS",,,,,,"Allele frequencies; Forensic; Mexico; STR",,,,,,"STR data for 15 loci in a population sample from the central region of Mexico",,"Article" "46559","123456789/35008",,"Medina-Ceja, L., Departamento de Biología Celular Y Molecular, Centro Universitario de Ciencias Biológicas Y Agropecuarias, Universidad de Guadalajara, Nextipac, Zapopan, Jalisco, Mexico, Departamento de Biología Celular Y Molecular, Centro Universitario de Ciencias Biológicas Y Agropecuarias, Universidad de Guadalajara, Ctra. Guadalajara-Nogales, km. 15,5, Nextipac, Zapopan, Jalisco, Mexico; Guerrero-Cazares, H., Posgrado en Ciencias Biomédicas, Centro Universitario de Ciencias Biológicas Y Agropecuarias, Universidad de Guadalajara, Nextipac, Zapopan, Jalisco, Mexico; Canales-Aguirre, A., Posgrado en Ciencias Biomédicas, Centro Universitario de Ciencias Biológicas Y Agropecuarias, Universidad de Guadalajara, Nextipac, Zapopan, Jalisco, Mexico; Morales-Villagrán, A., Departamento de Biología Celular Y Molecular, Centro Universitario de Ciencias Biológicas Y Agropecuarias, Universidad de Guadalajara, Nextipac, Zapopan, Jalisco, Mexico; Feria-Velasco, A., Departamento de Biología Celular Y Molecular, Centro Universitario de Ciencias Biológicas Y Agropecuarias, Universidad de Guadalajara, Nextipac, Zapopan, Jalisco, Mexico",,"Medina-Ceja, L.
Guerrero-Cazares, H.
Canales-Aguirre, A.
Morales-Villagran, A.
Feria-Velasco, A.",,"2007",,"Aims. The article highlights the general structural characteristics, functional properties and distribution of glutamate transporters, as well as the role they play in epilepsy and oxidative stress. Development. Transporters of amino acids such as glutamate are considered to be proteins that are extremely important in the central nervous system because they participate in the capture of the neurotransmitter following its release in the synaptic cleft, thus putting an end to its effect and limiting glutamate-mediated excitability. These proteins belong to the family of Na+/Kx+ dependent transporters. A growing body of evidence has been gathered to show that these transporters are involved in several neuronal disorders, such as epilepsy and cerebral ischaemia. In this regard, it is considered that some defect in the structure of the transporters could affect their functioning and, therefore, favour the hyperexcitability produced by glutamate; this in turn would lead to the pathological disorders that are found in epilepsy. Conclusions. A detailed study of the structure and functioning of these transporters, as well as the role they play in the more common neurological diseases, such as epilepsy, would afford us a clearer view of new therapeutic alternatives with which to fight this kind of neuronal disorder in the future. " 2007, Revista de Neurología.
URI: http://hdl.handle.net/20.500.12104/44780
http://www.scopus.com/inward/record.url?eid=2-s2.0-37349045008&partnerID=40&md5=466869ad8e5234b4ac0ef059be01fd1f
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