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Title: Single nucleotid polymorphisms of adhesion molecules and clinical parameters in rheumatoid arthritis [Polimorfismos de nucleótido simple en moléculas de adhesión y parámetros clúnicos en artritis reumatoide]
Author: Navarro-Hernandez, R.E.
Vazquez-Del Mercado, M.
Oregon-Romero, E.
Munoz-Valle, J.F.
Issue Date: 2007
Abstract: The aim was to investigate the relationship between E-selectin, ICAM1 and VCAM1 polymorphisms with lipid profile and rheumatoid arthritis (RA) clinical inflammation markers. Sixty RA patients classified according to 1987 American College of Rheumatology (ACR) criteria and 60 unrelated healthy controls (HS) defined as Mexican-mestizo population, were included. The genotypes were characterized using the polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) technique. The ESR (erythrocyte sedimentation rate), RF (rheumatoid factor), fibrinogen (FB), C-reactive protein (CRP) and lipid profile were measured by routine methods. Statistical analysis was performed using SPSS v10.0. The significant Pearson's correlations were: ESR with CRP, RF, FB and HDLc, (r=0.507, 0.296, 0.475, and -0.308, respectively); CRP with FB (r=0.613), p<0.05. The results showed an association with A allele of ICAM1 polymorphism and serum levels of HDLc and LDLc; and Apo-B and FR showed an association with C allele of VCAM1 polymorphism (p<0.05). Data shows that FB and HDLc levels, and ICAM1 polymorphism allele 721A and VCAM1 polymorphism allele 1238G are associated with clinical inflammation markers in RA. Our Mexican-mestizo population showed differences with many reports (from English, American, Turkish, Japanese, Chinese, Italian, and Korean populations).
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