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|Title:||SERS and ANFIS: Fast identification of the presence of retrovirus in CD4 cells, cause of AIDS|
|Abstract:||Rheumatoid arthritis (RA) is an inflammatory autoimmune disease of unknown etiology. Many cytokines have been found to be associated with RA pathogenesis and among them is macrophage migration inhibitory factor (MIF). The aim of this study was to determine whether MIF serum levels are associated with RA course, clinical activity, and clinical biomarkers of the disease. MIF levels were determined in serum samples of 54 RA patients and 78 healthy subjects (HS) by enzyme-linked immunosorbent assay (ELISA). Disease activity was evaluated using the DAS28 score. Patients were subgrouped according to disease activity and years of evolution of disease. Statistical analysis was carried out by SPSS 10.0 and GraphPad Prism 5 software. RA patients presented increased levels of MIF as compared to HS. MIF levels were raised on early stages of RA and tend to decrease according to years of evolution. Moreover, MIF levels positively correlated with rheumatoid factor in RA patients and with C reactive protein in all individuals studied. Our findings suggest that MIF plays a role in early stages of RA. " Springer-Verlag 2011.",,,,,,"10.1007/s00296-011-1951-6",,,"http://hdl.handle.net/20.500.12104/44497","http://www.scopus.com/inward/record.url?eid=2-s2.0-84866236870&partnerID=40&md5=2c2ffb413c4b020da80114db36a5afc7|
WOS",,,,"Index Medicus;Adult;Aged;Antirheumatic Agents/tu [Therapeutic Use];Arthritis, Rheumatoid/bl [Blood];Arthritis, Rheumatoid/di [Diagnosis];Arthritis, Rheumatoid/dt [Drug Therapy];Arthritis, Rheumatoid/im [Immunology];Biological Markers/bl [Blood];C-Reactive Protein/an [Analysis];Case-Control Studies;Cross-Sectional Studies;Enzyme-Linked Immunosorbent Assay;Female;Humans;Intramolecular Oxidoreductases/bl [Blood];Macrophage Migration-Inhibitory Factors/bl [Blood];Male;Mexico;Middle Aged;Prognosis;Rheumatoid Factor/bl [Blood];Severity of Illness Index;Up-Regulation;Young Adult",,"Clinical activity; Disease evolution; MIF; Rheumatoid arthritis",,,,,,"Serum levels of macrophage migration inhibitory factor are associated with rheumatoid arthritis course",,"Article" "46269","123456789/35008",,"De La Torre, J., Instituto Tecnológico y de Estudios Superiores de Monterrey, Aguascalientes, Mexico; Luna, F., Instituto Tecnológico de Aguascalientes, Mexico; Martínez, J., Instituto Tecnológico de Aguascalientes, Mexico; Padilla, A., Laboratorio de Inteligencia Artificial, UA de Aguascalientes, Mexico; Mora, M., Centro Universitario de Los Lagos, Universidad de Guadalajara, Mexico",,"De La Torre, J.
Mora, M.",,"2008",,"The harmful presence of retrovirus in CD4cells of the human immune system can result in the syndrome of human immunodeficiency known as AIDS, a disease that has extended widely across the entire planet.This paper proposes to obtain characteristic RAMAN spectra with specific peaks detected, eliminating the noise of high frequency (HF) and fluorescence of the signal obtained with SERS and improved with ANFIS. With the spectra cleaned of this noise (HF and fluorescence) the characteristic RAMAN spectra of each microorganism or retrovirus (HIV) in this case is defined. This method provides the specialists with important clinical tools to express an efficient diagnosis of AIDS. " 2008 Springer Berlin Heidelberg.
|Appears in Collections:||Producción científica UdeG|
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