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Title: Self-organizing squad and crowd formation for emergency evacuations in serious games
Author: Gonzalez-Burgos, I.
Rivera-Cervantes, M.C.
Velazquez-Zamora, D.A.
Feria-Velasco, A.
García-Segura, L.M.
Issue Date: 2012
Abstract: Some selective estrogen receptor modulators, such as raloxifene and tamoxifen, are neuroprotective and reduce brain inflammation in several experimental models of neurodegeneration. In addition, raloxifene and tamoxifen counteract cognitive deficits caused by gonadal hormone deprivation in male rats. In this study, we have explored whether raloxifene and tamoxifen may regulate the number and geometry of dendritic spines in CA1 pyramidal neurons of the rat hippocampus. Young adult male rats were injected with raloxifene (1mg/kg), tamoxifen (1mg/kg), or vehicle and killed 24h after the injection. Animals treated with raloxifene or tamoxifen showed an increased numerical density of dendritic spines in CA1 pyramidal neurons compared to animals treated with vehicle. Raloxifene and tamoxifen had also specific effects in the morphology of spines. These findings suggest that raloxifene and tamoxifen may influence the processing of information by hippocampal pyramidal neurons by affecting the number and shape of dendritic spines. " 2012 Ignacio Gonzlez-Burgos et al.",,,,,,"10.1155/2012/309494",,,"","",,,,,,,,"Neural Plasticity",,,,"2012",,"Scopus
WOS",,,,,,,,,,,,"Selective estrogen receptor modulators regulate dendritic spine plasticity in the hippocampus of male rats",,"Article" "46223","123456789/35008",,"Cesar, G.-G., CUCEA-Universidad de Guadalajara, Periferico Norte 799, Guadalajara, Mexico; Victor, L.-R., CUCEA-Universidad de Guadalajara, Periferico Norte 799, Guadalajara, Mexico; Luga, H., CUCEA-Universidad de Guadalajara, Periferico Norte 799, Guadalajara, Mexico",,"Cesar, G.-G.
Victor, L.-R.
Luga, H.",,"2012",,"This paper presents a novel approach to organize agents into groups or squads for evacuation simulation. Previous work containing personality profiles is used to simulate social interaction and leadership roles, as well as comparing this approach to centralized, partlyautonomous and randomized formations in terms of survivability of squad members during a simulated evacuation. " 2012 EUROSIS-ETI.
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