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|Title:||Role of fibroblast growth factor receptors in astrocytic stem cells|
|Abstract:||In this chapter, some state estimation schemes used in bioprocesses engineering are firstly reviewed with particular emphasis on the so-called nonlinear observers. Second, two simple robust nonlinear observers are proposed and applied in a number of bioprocesses. The first estimation scheme is a generalized asymptotic observer which has demonstrated to be robust in the face of a complete lack of knowledge of the process nonlinearities whereas the second one has shown to be robust in the face of both, the system nonlinearities and the input uncertainty and yields guaranteed intervals for the non-measured variables from the available measurements. The design of both observer schemes are detailed for a general dynamical system which may be applied in a number of bioprocesses. The interval observer is further developed for fault detection and diagnosis purposes. In addition, detailed stability analysis are developed for both observers. Finally, these observers are tested in an actual experimental pilot plant used for the anaerobic digestion of wine vinasses. Key results are presented and discussed. " 2007 Springer-Verlag Berlin Heidelberg.",,,,,,"10.1007/978-3-540-73188-7_5",,,"http://hdl.handle.net/20.500.12104/44310","http://www.scopus.com/inward/record.url?eid=2-s2.0-35648987696&partnerID=40&md5=f2a03e1c44ddacc6f404df40feac7115",,,,,,,,"Lecture Notes in Control and Information Sciences",,"119|
WOS",,,,,,,,,,,,"Robust nonlinear observers for bioprocesses: Application to wastewater treatment",,"Review" "46095","123456789/35008",,,"Pozos Ponce, Fernando",,"1997",,,,,,,,,,"1665-0565",,"http://hdl.handle.net/20.500.12104/44316",,"Español",,,,"9",,"Espiral. Estudios sobre estado y sociedad",,"101-120",,"3",,"CLASE",,,,,,,,"Economía industrial",,"Hacia una nueva generación de pequeñas industrias. El caso de Guadalajara",,,,"journalArticle", "46104","123456789/35008",,"Galvez-Contreras, A.Y., Neuroscience Lab, Facultad de Psicologia, Universidad de Colima, Colima, COL. 28040, Mexico, Department of Neuroscience, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco 44340, Mexico; Gonzalez-Castaneda, R.E., Department of Neuroscience, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco 44340, Mexico; Luquin, S., Department of Neuroscience, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco 44340, Mexico; Gonzalez-Perez, O., Neuroscience Lab, Facultad de Psicologia, Universidad de Colima, Colima, COL. 28040, Mexico, Department of Neuroscience, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco 44340, Mexico",,"Galvez-Contreras, A.Y.
Gonzalez-Perez, O.",,"2012",,"There are two well-defined neurogenic regions in the adult brain, the subventricular zone (SVZ) lining the lateral wall of the lateral ventricles and, the subgranular zone (SGZ) in the dentate gyrus at the hippocampus. Within these neurogenic regions, there are neural stem cells with astrocytic characteristics, which actively respond to the basic fibroblast growth factor (bFGF, FGF2 or FGF-?) by increasing their proliferation, survival and differentiation, both in vivo and in vitro. FGF2 binds to fibroblast growth factor receptors 1 to 4 (FGFR1, FGFR2, FGFR3, FGFR4). Interestingly, these receptors are differentially expressed in neurogenic progenitors. During development, FGFR-1 and FGFR-2 drive oligodendrocytes and motor neuron specification. In particular, FGFR-1 determines oligodendroglial and neuronal cell fate, whereas FGFR-2 is related to oligodendrocyte specification. In the adult SVZ, FGF-2 promotes oligodendro-gliogenesis and myelination. FGF-2 deficient mice show a reduction in the number of new neurons in the SGZ, which suggests that FGFR-1 is important for neuronal cell fate in the adult hippocampus. In human brain, FGF-2 appears to be an important component in the anti-depressive effect of drugs. In summary, FGF2 is an important modulator of the cell fate of neural precursor and, promotes oligodendrogenesis. In this review, we describe the expression pattern of FGFR2 and its role in neural precursors derived from the SVZ and the SGZ. " 2012 Bentham Science Publishers.
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