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Title: Recombinant murine IL-12 promotes a protective Th1/cellular response in mongolian gerbils infected with sporothrix schenckii
Author: Flores-Garcia, A.
Velarde-Felix, J.S.
Garibaldi-Becerra, V.
Rangel-Villalobos, H.
Torres-Bugarin, O.
Zepeda-Carrillo, E.A.
Ruiz-Bernes, S.
Ochoa-Ramirez, L.A.
Issue Date: 2015
Abstract: Sporotrichosis is a cutaneous fungal infection caused by Sporothrix schenckii. It is known to be mainly contained by Th1 responses. As IL-12 is crucial for Th1 response, we investigated if treatment with recombinant murine IL-12 (rmIL-12) promoted Th1 immunity and/or clinical improvement in an experimental sporotrichosis gerbil model. Gerbils were inoculated with S. schenckii in the footpad and treated with rmIL- 12. Seven days post infection there was a significant increase in macrophage phagocytosis and oxidative burst, and in delayed-type hypersensitivity (DTH) reaction in rmIL-12 treated gerbils, as well as a ~10-fold increase of serum IFN-gamma and a decrease of IL-4 and IL-10. Moreover, rmIL-12 substantially decreased (~70%) S. schenckii burden in liver and spleen and improved the clinical outcome preventing footpad ulcer and tail nodules observed in untreated gerbils. Our study demonstrates that rmIL-12 promotes Th1 immune response against S. schenckii favouring its clearance and preventing clinical symptoms. � 2015 Edizioni Scientifiche per l�Informazione su Farmaci e Terapia.
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