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|Title:||Quasistationary solutions of self-gravitating scalar fields around black holes|
|Abstract:||Background and Aim: Development of hepatic cirrhosis involves oxidative stress, inflammation, hepatic stellate cells (HSC)s activation and fibrosis. On the other hand, quercetin, a natural flavonoid is a potent antioxidant and activator of superoxide dismutase and catalase. The aim was to determinate the effect of quercetin on HSCs and development of hepatic fibrosis. Methods: Wistar male rats were chronically intoxicated with CCl4 for 8 weeks and concomitantly treated with 100mg/kg per day of quercetin. Oxidative state, inflammation and fibrosis were evaluated. Effect of quercetin on apoptosis of HSC was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling reaction. Results: Sixty percent of reduction in fibrosis index was observed with quercetin treatment compared with control animals. Considerable reduction on hepatic enzymes was detected in the quercetin group. Expression of pro-fibrotic genes (transforming growth factor-? [TGF-?], Collagen 1? [Col-1?] and connective tissue growth factor [CTGF]) were decreased by quercetin. Quercetin increased gene expression and functional activity of antioxidant enzymes superoxide dismutase and catalase. Inflammatory index was highly reduced as determined by H-E staining and pro-inflammatory cytokines expression and nuclear factor-?B activation were also inhibited. A significant reduction of 65% on activated HSC number was detected when rats were treated with quercetin. Quercetin also induced activation of matrix metalloproteinases MMP2 and MMP9 contributing to decreased index of fibrosis. Conclusions: Treatment with quercetin reduces oxidation and inflammation and also prevents liver fibrosis, through induction of HSC apoptosis and activation of MMPs. " 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.",,,,,,"10.1111/j.1440-1746.2012.07262.x",,,"http://hdl.handle.net/20.500.12104/44032","http://www.scopus.com/inward/record.url?eid=2-s2.0-84869784553&partnerID=40&md5=0591bcc4dbefe5fe4d9195d7fd3a7216|
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=22989100",,,,,,"12",,"Journal of Gastroenterology and Hepatology (Australia)",,"1865
WOS",,,,"Index Medicus;Animals;Disease Models, Animal;Extracellular Matrix/me [Metabolism];Hepatic Stellate Cells/pa [Pathology];Inflammation/pc [Prevention & Control];Liver Cirrhosis/dt [Drug Therapy];Liver Cirrhosis/me [Metabolism];Liver Cirrhosis/pa [Pathology];Male;Metalloproteases/me [Metabolism];Oxidative Stress/de [Drug Effects];Quercetin/pd [Pharmacology];Quercetin/tu [Therapeutic Use];Rats;Rats, Wistar;Tissue Inhibitor of Metalloproteinases/me [Metabolism]",,"Anti-inflammatory properties; Hepatic fibrosis; Hepatic stellate cells; Quercetin",,,,,,"Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro-fibrogenic/anti-fibrogenic molecules balance",,"Article" "45790","123456789/35008",,"Klimov, A.B., Departamento de Física, Universidad de Guadalajara, Revolución 1500, 44420 Guadalajara, Jalisco, Mexico; Sánchez-Soto, L.L., Departamento de óptica, Facultad de Física, Universidad Complutense, 28040 Madrid, Spain; De Guise, H., Department of Physics, Lakehead University, Thunder Bay, Ont. P7B 5E1, Canada; Bjork, G., Department of Microelectronics, Royal Institute of Technology (KTH), Electrum 229, SE-164 40 Kista, Sweden
Klimov, Andrei B., Universidad de Guadalajara. Centro Universitario de Ciencias Exactas e Ingenierías",,"Klimov, Andrei B.
De Guise, H.
Bjork, G.",,"2004",,"We consider various approaches to treat the phases of a qutrit. Although it is possible to represent qutrits in a convenient geometrical manner by resorting to a generalization of the Poincare sphere, we argue that the appropriate way of dealing with this problem is through phase operators associated with the algebra su(3). The rather unusual properties of these phases are caused by the small dimension of the system and are explored in detail. We also examine the positive operator-valued measures that can describe the qutrit phase properties.",,,,,,"10.1088/0305-4470/37/13/012",,,"http://hdl.handle.net/20.500.12104/44011","http://www.scopus.com/inward/record.url?eid=2-s2.0-1842817588&partnerID=40&md5=885ee188680e803d32513a1029baa39a",,,,,,"13",,"Journal of Physics A: Mathematical and General",,"4097
WOS",,,,,,,,,,,,"Quantum phases of a qutrit",,"Article" "45809","123456789/35008",,"Sanchis-Gual, N., Departamento de Astronomía y Astrofísica, Universitat de Valéncia, Dr. Moliner 50Burjassot (Valéncia), Spain; Degollado, J.C., Departamento de Ciencias Computacionales, Centro Universitario de Ciencias Exactas e Ingeniería, Universidad de Guadalajara, Avenida Revolución 1500Col. Olímpica, Guadalajara, Jalisco, Mexico; Montero, P.J., Max-Planck-Institute for Astrophysik, Karl-Schwarzschild-Strasse 1Garching bei München, Germany; Font, J.A., Departamento de Astronomía y Astrofísica, Universitat de Valéncia, Dr. Moliner 50Burjassot (Valéncia), Spain, Observatori Astronúmic, Universitat de Valéncia, C/Catedrático José Beltrán 2Paterna (Valéncia), Spain",,"Sanchis-Gual, N.
Font, J.A.",,"2015",,"Recent perturbative studies have shown the existence of long-lived, quasistationary configurations of scalar fields around black holes. In particular, such configurations have been found to survive for cosmological time scales, which is a requirement for viable dark matter halo models in galaxies based on such types of structures. In this paper we perform a series of numerical relativity simulations of dynamical nonrotating black holes surrounded by self-gravitating scalar fields. We solve numerically the coupled system of equations formed by the Einstein and the Klein-Gordon equations under the assumption of spherical symmetry using spherical coordinates. Our results confirm the existence of oscillating, long-lived, self-gravitating scalar field configurations around nonrotating black holes in highly dynamical spacetimes with a rich scalar field environment. Our numerical simulations are long-term stable and allow for the extraction of the resonant frequencies to make a direct comparison with results obtained in the linearized regime. A by-product of our simulations is the existence of a degeneracy in plausible long-lived solutions of Einstein equations that would induce the same motion of test particles, either with or without the existence of quasibound states. " 2015 American Physical Society.
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