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|Title:||Electromagnetism and perfect fluids interplay in multidimensional spacetimes|
|Abstract:||The liver is the largest internal organ of the body, which may suffer acute or chronic injury induced by many factors, leading to cirrhosis and hepatocarcinoma. Cirrhosis is the irreversible end result of fibrous scarring and hepatocellular regeneration, characterized by diffuse disorganization of the normal hepatic structure, regenerative nodules and fibrotic tissue. Cirrhosis is associated with a high co-morbidity and mortality without effective treatment, and much research has been aimed at developing new therapeutic strategies to guarantee recovery. Liver-based gene therapy has been used to downregulate specific genes, to block the expression of deleterious genes, to delivery therapeutic genes, to prevent allograft rejection and to augment liver regeneration. Viral and non-viral vectors have been used, with viral vectors proving to be more efficient. This review provides an overview of the main strategies used in liver-gene therapy represented by non-viral vectors, viral vectors, novel administration methods like hydrodynamic injection, hybrids of two viral vectors and blocking molecules, with the hope of translating findings from the laboratory to the patient's bed-side. " 2015 Baishideng Publishing Group Inc. All rights reserved.",,,,,,"10.3748/wjg.v21.i13.3813",,,"http://hdl.handle.net/20.500.12104/43114","http://www.scopus.com/inward/record.url?eid=2-s2.0-84926615871&partnerID=40&md5=181b1ff5a59f9fccdb95d85f483a77c6|
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25852266",,,,,,"13",,"World Journal of Gastroenterology",,"3813
MEDLINE",,,,"Index Medicus",,"Gene therapy; Hepatic fibrosis; Non-viral vectors; Viral vectors",,,,,,"New gene therapy strategies for hepatic fibrosis",,"Review" "42979","123456789/35008",,"Mitskievich, N.V., Department of Physics, CUCEI, Universidad de Guadalajara, Apartado Postal 1-2011, C.P. 44100, Guadalajara, Jalisco, Mexico",,"Mitskievich, N.V.",,"2008",,"We consider fields in (D > 2)-dimensional spacetime, whose potential is r-form (skew-symmetric tensor of rank r), the field tensor F being its exterior derivative and the Lagrangian, a function of the quadratic invariant I of this tensor. It is shown that vector field (r = 1) describes electromagnetic field only for D = 4. In particular, for D = 3 and the Lagrangean L as any function of the above-mentioned invariant, the (r = 1)-field has energy-momentum tensor identical with that of a perfect fluid whose equation of state depends on the choice of L(I). " 2008 World Scientific Publishing Co. Pte. Ltd.
|Appears in Collections:||Producción científica UdeG|
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