Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/43067
Title: Conjugated bilirubin affects cytokine profiles in hepatitis A virus infection by modulating function of signal transducer and activator of transcription factors
Author: Alanis, A.Y.
Sanchez, E.N.
Ruiz-Velazquez, E.
Leon, B.S.
Issue Date: 2011
Abstract: This paper presents on-line blood glucose level modeling for Type 1 Diabetes Mellitus (T1DM) patients. The model is developed using a recurrent neural network trained with an extended Kalman filter based algorithm in order to develop an affine model, which captures the nonlinear behavior of the blood glucose metabolism. The goal is to derive an on-line dynamical mathematical model of the T1DM for the response of a patient to meal and subcutaneous insulin infusion. Simulation results are utilized for identification and for testing the applicability of the proposed scheme. " 2011 IEEE.",,,,,,"10.1109/IJCNN.2011.6033474",,,"http://hdl.handle.net/20.500.12104/43067","http://www.scopus.com/inward/record.url?eid=2-s2.0-80054752561&partnerID=40&md5=2eb2c4d9b43191fe9a580ae9437afb27",,,,,,,,"Proceedings of the International Joint Conference on Neural Networks",,"2018
2023",,,,"Scopus",,,,,,"Kalman Filtering; Multilayer Perceptron; Prediction; Recurrent Neural Networks; Type 1 Diabetes Mellitus",,,,,,"Neural model of blood glucose level for type 1 diabetes mellitus patients",,"Conference Paper" "42082","123456789/35008",,"Castro-García, F.P., Unidad de Inmunovirología, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Mexico; Corral-Jara, K.F., Unidad de Inmunovirología, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Mexico; Escobedo-Melendez, G., Servicio de Infecto-Pediatría, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico, Servicio de Hematología y Oncología Pediátrica, Hospital Civil de Guadalajara Hospital Civil de Guadalajara Juan I. Menchaca.Guadalajara, Mexico; Sandoval-Hernandez, M.A., Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de MéxicoCuernavaca, Mexico; Rosenstein, Y., Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de MéxicoCuernavaca, Mexico; Roman, S., Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Mexico, Servicio de Biología Molecular, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico; Panduro, A., Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Mexico, Servicio de Biología Molecular, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico; Fierro, N.A., Unidad de Inmunovirología, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Mexico, Servicio de Biología Molecular, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico
Panduro-Cerda, Arturo., Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud",,"Castro-García, F.P.
Corral-Jara, K.F.
Escobedo-Melendez, G.
Sandoval-Hernandez, M.A.
Rosenstein, Y.
Roman, S.
Panduro-Cerda, Arturo
Fierro, N.A.",,"2014",,"Summary: Hepatitis A virus (HAV) infection is the major cause of acute liver failure in paediatric patients. The clinical spectrum of infection is variable, and liver injury is determined by altered hepatic enzyme function and bilirubin concentration. We recently reported differences in cytokine profiles between distinct HAV-induced clinical courses, and bilirubin has been recognized as a potential immune-modulator. However, how bilirubin may affect cytokine profiles underlying the variability in the course of infection has not been determined. Herein, we used a transcription factor (TF) binding site identification approach to retrospectively analyse cytokine expression in HAV-infected children and to predict the entire set of TFs associated with the expression of specific cytokine profiles. The results suggested that modulation of the activity of signal transducers and activators of transcription proteins (STATs) may play a central role during HAV infection. This led us to compare the degree of STAT phosphorylation in peripheral blood lymphoid cells (PBLCs) from paediatric patients with distinct levels of conjugated bilirubin (CB). Low CB levels in sera were associated with increased STAT-1 and STAT-5 phosphorylation. A positive correlation was observed between the serum interleukin-6 (IL-6) content and CB values, whereas higher levels of CB correlated with reduced serum IL-8 values and with a reduction in the proportion of PBLCs positive for STAT-5 phosphorylation. When CB was used to stimulate patients' PBLCs in vitro, the levels of IL-6 and tumour necrosis factor-? were increased. The data showed that bilirubin plays a role in STAT function and affects cytokine profile expression during HAV infection. " 2014 John Wiley & Sons Ltd.
URI: http://hdl.handle.net/20.500.12104/40303
http://www.scopus.com/inward/record.url?eid=2-s2.0-84911964531&partnerID=40&md5=8b9243db54949c9cb178d28263161240
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=24943111
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