Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/42680
Title: Massive myeloid sarcoma affecting the central nervous system, mediastinum, retroperitoneum, liver, and rectum associated with acute myeloblastic leukaemia: A case report
Author: Best-Aguilera, C.R.
Vazquez-Del Mercado, M.
Munoz-Valle, J.F.
Herrera-Zarate, L.
Navarro-Hernandez, R.E.
Martin-Marquez, B.T.
Oregon-Romero, E.
Ruiz-Quezada, S.
Bonilla, G.M.
Lomeli-Guerrero, A.
Issue Date: 2005
Abstract: Myeloid sarcomas are extramedullary tumours with granulocytic precursors. When associated with acute myelogenous leukaemia (AML), these tumours usually affect no more than two different extramedullary regions. This report describes a myeloid sarcoma associated with AML with tumour formation at five anatomical sites. The patient was a 37 year old man admitted in September 1999 with a two month history of weight loss, symptoms of anaemia, rectal bleeding, and left facial nerve palsy. The anatomical sites affected were: the rectum, the right lobe of the liver, the mediastinum, the retroperitoneum, and the central nervous system. A bone marrow smear was compatible with AML M2. Flow cytometry showed that the peripheral blood was positive for CD4, CD11, CD13, CD14, CD33, CD45, and HLA-DR. A karyotypic study of the bone marrow revealed an 8;21 translocation. The presence of multiple solid tumours in AML is a rare event. Enhanced expression of cell adhesion molecules may be the reason why some patients develop myeloid sarcomas.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-20144375630&partnerID=40&md5=3e105750348108f4368ca2957bab914f
http://hdl.handle.net/20.500.12104/42680
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