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|Title:||Macrophage migration inhibitory factor: Association of -794 CATT5-8 and -173 G>C polymorphisms with TNF-? in systemic lupus erythematosus|
|Author:||De la Cruz-Mosso, U.|
|Abstract:||Macrophage migration inhibitory factor (MIF) is an upstream immunoregulatory cytokine associated with the pathogenesis of autoimmune inflammatory diseases. There is evidence that MIF functions in a positive feedback loop with TNF-? that could perpetuate the inflammatory process in systemic lupus erythematosus (SLE). In this case-control study we investigated whether commonly occurring functional MIF polymorphisms are associated with SLE as well as with MIF and TNF-? serum levels in a Mexican-Mestizo population. Genotyping of the -794 CATT5-8 (rs5844572) and -173 G>C (rs755622) MIF polymorphisms was performed by PCR and PCR-RFLP, respectively in 186 SLE patients and 200 healthy subjects. MIF and TNF-? serum levels were determined by ELISA. A significant increase of MIF and TNF-? levels was found in SLE patients. According to a genetic model, we found a significant association of genotypes carrying the -794 CATT7 and -173*C risk alleles with susceptibility to SLE and with a significant increase of TNF-?. In conclusion, MIF gene polymorphisms are associated with SLE susceptibility and with an increase of TNF-? serum levels in a Mexican-Mestizo population. � 2014 American Society for Histocompatibility and Immunogenetics.|
|Appears in Collections:||Producción científica UdeG|
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