Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/42476
Title: Paternal isodisomy 7q secondary to monosomy 7 at recurrence in a Down syndrome child with acute myelogenous leukemia
Author: Felix, J.S.V.
Cazarez-Salazar, S.
Rios-Tostado, J.J.
Flores-García, A.
Rangel-Villalobos, H.
Murillo-Llanes, J.
Issue Date: 2012
Abstract: Several human genetic variants have been associated with susceptibility or resistance to leprosy. The aim of this study was to assess whether gene polymorphisms of -308 G/A TNF-? and -819 T/C IL-10 are associated with lepromatous leprosy in Mexican mestizos patients from northwest Mexico. We genotyped these polymorphisms by means of polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLPs) in 68 patients with lepromatous leprosy and 144 healthy Mexican Mestizos controls. We found that the -308G TNF-? allele was predominant in both cases (94 3%) and controls (92 3%) without statistical significance and the frequencies of -819C IL-10 allele were also similar for the cases (56 0%) and controls (59 0%). These negative findings suggest that other genes or polymorphisms may be important in the susceptibility to leprosy infection in the Mexican mestizos. " Lepra.",,,,,,,,,"http://hdl.handle.net/20.500.12104/42476","http://www.scopus.com/inward/record.url?eid=2-s2.0-84859336844&partnerID=40&md5=d7b395af73eba7789fb61cb197275b20",,,,,,"1",,"Leprosy Review",,"34
39",,"83",,"Scopus
WOS",,,,,,,,,,,,"Lack of effects of the TNF-? and IL-10 gene polymorphisms in Mexican patients with lepromatous leprosy",,"Article" "45275","123456789/35008",,"Picos-Cárdenas, V.J., Universidad de Guadalajara and División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Meza-Espinoza, J.P., Universidad de Guadalajara and División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Gutiérrez-Angulo, M., Universidad de Guadalajara and División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Esparza-Flores, M.A., Departamento de Hematología, Hospital de Pediatría, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Ayala-Madrigal, M.L., Departamento de Fisiología, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Hansmann, I., Institut fuer Humangenetik und Medizinishe Biologie, Universitaet Halle-Wittenberg, HalleSaale, Germany; González, G.J.R., Universidad de Guadalajara and División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico",,"Picos-Cardenas, V.J.
Meza-Espinoza, J.P.
Gutierrez-Angulo, M.
Esparza-Flores, M.A.
Ayala-Madrigal, M.L.
Hansmann, I.
Gonzalez, G.J.R.",,"2002",,"We report a boy with Down syndrome and leukemia who acquired uniparental isodisomy of chromosome 7q as a secondary chromosomal change during recurrence of the disease. His karyotype before therapy was 46,XY,der(1)t(1;1)(p36;q32),-7,+21c[17]/46,idem,del(9)(p22)[10], whereas at recurrence it was 46,XY,der(1)t(1;1)(p36;q32,-7,der(7)(qter?p22?pter
URI: http://hdl.handle.net/20.500.12104/43496
http://www.scopus.com/inward/record.url?eid=2-s2.0-0037089518&partnerID=40&md5=e9b5be853bb029d476ea6611e83b9f9a
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=12034527
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