Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/42458
Title: L-5178-Y lymphoma associated immunosuppression in Balb/c mice
Author: Daneri-Navarro, Adrián.
Del Toro-Arreola, A.
García-Velazco, J.C.
Del Toro-Arreola, S.
Orbach-Arbouys, S.
Bravo-Cuellar, A.
Issue Date: 1995
Abstract: Lymphoma L-5178-Y bearing Balb/c mice were unable to mount a delayed-type hypersensitivity reaction to dinitrofluorobenzene (DNFB). A suppressor factor present in the ascitis of these mice inhibited the response if given during DNFB sensitization, but not during challenge. The factor was not present in lymphoma-bearing Balb/c nu/nu mice. It appeared to be a 35-66 kDa protein. Non-specific esterase staining indicated that the spleens of tumor-bearing and ascitis-injected mice contained a large excess of macrophages. Our observation that the suppressor factor prevented the very start of the immune response may indicate why immunostimulation is difficult to obtain in cancer bearing hosts. © 1995 Elsevier, Paris.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-0028946047&partnerID=40&md5=9fcc15b20b5066ec6c1beb5e6f704529
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=7749078
http://hdl.handle.net/20.500.12104/42458
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