Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/42442
Title: Isosorbide dinitrate spray as therapeutic strategy for treatment of chronic venous ulcers
Author: Larios-Duran, E.R.
Antano-Lopez, R.
Issue Date: 2011
Abstract: A quantitative kinetic description of the adsorption of bromide on mercury is developed by combination of complementary approaches to the adsorption impedance data. Equivalent-circuit modeling is matched with mechanistic models. The resulting descriptions permit the estimation of absolute adsorption and desorption rate constants for Br- on Hg electrode by assuming either a Langmuir or a Frumkin adsorption isotherm. It is found that adsorption-desorption dynamics for the Hg/Br- system is well described by the transfer function based on the Frumkin isotherm, indicating a predominant role of adsorbate-adsorbate interactions. " 2011 Elsevier B.V. All rights reserved.",,,,,,"10.1016/j.jelechem.2011.04.009",,,"http://hdl.handle.net/20.500.12104/42442","http://www.scopus.com/inward/record.url?eid=2-s2.0-79957841079&partnerID=40&md5=b93c403078d6741e55f4e11b95db9ee2",,,,,,"01-feb",,"Journal of Electroanalytical Chemistry",,"10
17",,"658",,"Scopus
WOS",,,,,,"Adsorption kinetics; Equilibrium adsorption mechanism; Frumkin isotherm; Impedance; Rate constants",,,,,,"Kinetic study of bromide adsorption on Hg by a combined equivalent-circuit reaction-mechanism modeling of EIS data",,"Article" "44198","123456789/35008",,"Sánchez-Vázquez, R., Unidad de Investigación Cardiovascular, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Briseño-Rodríguez, G., Unidad de Investigación Cardiovascular, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Cardona-Muñoz, E.G., Unidad de Investigación Cardiovascular, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Gálvez-Gastélum, F.J., Instituto de Biología Molecular en Medicina, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Sierra Mojada, 950, Col. Independencia; Totsuka-Sutto, S.E., Unidad de Investigación Cardiovascular, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; García-Benavides, L., Unidad de Investigación Cardiovascular, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Instituto de Biología Molecular en Medicina, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico",,"Sanchez-Vazquez, R.
Briseno-Rodriguez, G.
Cardona-Munoz, E.G.
Galvez-Gastelum, F.J.
Totsuka-Sutto, S.E.
García-Benavides, L.",,"2008",,"Venous ulcers are the most common form of leg ulcers, which induce lesion because of the loss of substances deposited on the damaged skin. Isosorbide dinitrate is a vasodilator with effects on both arteries and veins and induces opening of vascular layers. The objective is to study the effects of isosorbide dinitrate-spray in patients with chronic venous ulcers. Forty-five patients of both sexes with chronic venous ulcers were randomized to receive isosorbide dinitrate or placebo sprays daily for 3 months. The ulcers were measured and clinical characteristics were taken every 15 days during the treatment. Patients treated with isosorbide dinitrate showed an improvement of the ulcerated area (71.29%) compared with patients treated with placebo (54.35%). The histopathological study indicated an increment in the number of hypertrophic and hyperplasic capillaries. Macroscopically, the isosorbide dinitrate-treatment showed the best results, but it was only during the first 6 weeks of treatment. Patients with chronic venous ulcer receiving isosorbide dinitrate spray showed improvement. " 2008 Sage Publications.
URI: http://hdl.handle.net/20.500.12104/42419
http://www.scopus.com/inward/record.url?eid=2-s2.0-39149123121&partnerID=40&md5=b757ea6230dee523fca4821d8081cb2f
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