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Title: Is Yq11 the main critical segment in balance Y;Autosome translocations?
Author: Rivera, H.
Diaz-Castanos, L.
Issue Date: 1992
Abstract: Balanced Y;Autosome translocations seem to be associated with male infertility whenever the Y breakpoint is located into Yq11 (where the azoospermia factor maps) or near its boundaries. By analogy with the effect on female carriers' fertility of balanced X;Autosome translocations, the band Yq11 emerges as the critical segment. This hypothesis implies that the subjacent mechanism is an impaired expression of the azoospermia factor - either through its physical disruption or via a position effect - rather than a disorder of the sex bivalent inactivation during prophase I.
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