Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/42348
Title: Intracellular antigens released from Balb/c mice kidneys under chemically induced apoptosis and/or necrosis
Author: Ramirez-Sandoval, R.
Vazquez-del-Mercado, M.
Daneri-Navarro, Adrián.
Lopez-Robles, E.
Bollain-y-Goitia, J.J.
Avalos-Diaz, E.
Herrera-Esparza, R.
Issue Date: 2008
Abstract: The present investigation assesses the possible role of apoptosis and necrosis in intracellular antigen exposure of kidneys from Balb/c mice. Renal tissues were cultured and treated with chemicals to induce apoptosis and/or necrosis. The expression of intracellular antigens Sm, RNP, Ro and La were monitored with antibodies against these antigens. Main results confirm that renal intracellular antigens are released and exposed onto the surface of apoptotic and necrotic cells, therefore these antigens become an easy target of autoantibodies. This mechanism may be important in the lupus nephritis pathogenesis.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-55249104562&partnerID=40&md5=bec385efa35fba6e16d15d8aad0aea3a
http://hdl.handle.net/20.500.12104/42348
Appears in Collections:Producción científica UdeG

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