Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/42098
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dc.contributor.authorLudwiczek, O.
dc.contributor.authorVannier, E.
dc.contributor.authorMoschen, A.
dc.contributor.authorSalazar-Montes, A.
dc.contributor.authorBorggraefe, I.
dc.contributor.authorGabay, C.
dc.contributor.authorEnrich, B.
dc.contributor.authorKaser, A.
dc.contributor.authorSiegmund, B.
dc.contributor.authorDinarello, C.
dc.contributor.authorTilg, H.
dc.date.accessioned2015-09-15T18:09:54Z-
dc.date.available2015-09-15T18:09:54Z-
dc.date.issued2008
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-54349097080&partnerID=40&md5=e2aef450abf88a14d9878b6164d2cdd0
dc.identifier.urihttp://hdl.handle.net/20.500.12104/42098-
dc.description.abstractObjective. To assess the production of the endogenous IL-1 modulators IL-1 receptor antagonist (IL-1Ra), type I and II soluble IL-1 receptors (IL-1sRI and II) in patients with chronic liver disease (CLD). Material and methods. Plasma levels of IL-1beta (IL-1?) and IL-1 modulators were assessed in 126 CLD patients and 39 healthy controls. IL-1sRII was also measured in the supernatants of primary hepatocyte cultures. Results. Plasma IL-1sRI and IL-1Ra levels were significantly higher in cirrhotic CLD patients than in non-cirrhotic CLD patients and in controls. Levels did not depend on the etiology of CLD. Likewise, plasma IL-1? levels were elevated in CLD patients compared with those in controls. In contrast, IL-1sRII levels did not differ between CLD patients and controls. Cultures of human primary hepatocytes showed that IL-1sRII is induced by IL-1?, but not IL-6. Conclusions. In cirrhotic CLD patients elevated plasma IL-1? is not counteracted by endogenous levels of IL-1sRII, whereas high IL-1sRI is expected to neutralize the naturally occurring antagonist IL-1Ra, resulting in a dysregulation of the IL-1 system that might enhance pro-inflammatory activity of IL-1. � 2008 Informa UK Ltd.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyWOS
dc.titleImpaired counter-regulation of interleukin-1 by the soluble IL-1 receptor type II in patients with chronic liver disease
dc.typeArticle
dc.identifier.doi10.1080/00365520802179925
dc.relation.ispartofjournalScandinavian Journal of Gastroenterology
dc.relation.ispartofvolume43
dc.relation.ispartofissue11
dc.relation.ispartofpage1360
dc.relation.ispartofpage1365
dc.subject.keywordChronic liver disease; Cytokines; IL-1; IL-1 soluble receptors; Liver cirrhosis
dc.contributor.affiliationLudwiczek, O., Academic Teaching Hospital Hall, Tyrol, Austria; Vannier, E., Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, United States; Moschen, A., Christian Doppler Research Laboratory for Gut Inflammation, Division of Gastroenterology and Hepatology, Medical University Innsbruck, Austria; Salazar-Montes, A., PhD Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara (Sierra Mojada #950 Col. Independencia), Guadalajara Jalisco, Mexico; Borggraefe, I., Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, United States; Gabay, C., Division of Rheumatology, University Hospital, Geneva, Switzerland; Enrich, B., Christian Doppler Research Laboratory for Gut Inflammation, Division of Gastroenterology and Hepatology, Medical University Innsbruck, Austria; Kaser, A., Christian Doppler Research Laboratory for Gut Inflammation, Division of Gastroenterology and Hepatology, Medical University Innsbruck, Austria; Siegmund, B., Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO, United States; Dinarello, C., Division of Rheumatology, University Hospital, Geneva, Switzerland; Tilg, H., Academic Teaching Hospital Hall, Tyrol, Austria, Christian Doppler Research Laboratory for Gut Inflammation, Division of Gastroenterology and Hepatology, Medical University Innsbruck, Austria, Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Anichstrasse 35, AT-6020 Innsbruck, Austria
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