Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/42056
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dc.contributor.authorSanchez-Hernandez, P.E.
dc.contributor.authorZamora-Perez, A.L.
dc.contributor.authorFuentes-Lerma, M.
dc.contributor.authorRobles-Gomez, C.
dc.contributor.authorMariaud-Schmidt, R.P.
dc.contributor.authorGuerrero-Velazquez, C.
dc.date.accessioned2015-09-15T18:09:08Z-
dc.date.available2015-09-15T18:09:08Z-
dc.date.issued2011
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-79957970148&partnerID=40&md5=b26c193996fa53b58221a26c035d5d8b
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=21332601
dc.identifier.urihttp://hdl.handle.net/20.500.12104/42056-
dc.description.abstractObjective: The aim of this study was to compare the levels of interleukin-12 (IL-12) and IL-18 in gingival tissue and serum between patients with chronic (n=18) or aggressive periodontitis (n=12) and healthy subjects (HS) (n=9). Methods: Gingival tissue biopsies and serum were obtained from all study subjects. The tissue was homogenized and cytokines IL-12 and IL-18 were quantified by enzyme-linked immunosorbent assay. Results: Interleukin-12 levels in gingival tissue were significantly higher in aggressive periodontitis patients than in HS; serum IL-12 was significantly elevated in aggressive periodontitis relative to both chronic periodontitis (CP) and HS. IL-18 levels in gingival tissue showed no significant differences between the groups. Patients with CP showed significantly elevated levels of serum IL-18 compared with HS; however, the aggressive periodontitis group showed no significant differences with either the CP group or the HS. Conclusions: Our results showed higher levels of IL-12 in gingival tissue and serum of patients with aggressive periodontitis, and IL-18 was elevated in the serum of CP patients. The patterns of IL-12 and IL-18 are different in chronic and aggressive periodontitis; this finding suggests distinctive mechanisms of immunopathogenesis between these forms of periodontitis. � 2011 John Wiley & Sons A/S.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyWOS
dc.relation.isreferencedbyMEDLINE
dc.titleIL-12 and IL-18 levels in serum and gingival tissue in aggressive and chronic periodontitis
dc.typeArticle
dc.identifier.doi10.1111/j.1601-0825.2011.01798.x
dc.relation.ispartofjournalOral Diseases
dc.relation.ispartofvolume17
dc.relation.ispartofissue5
dc.relation.ispartofpage522
dc.relation.ispartofpage529
dc.subject.keywordInterleukin-12; Interleukin-18; Periodontitis
dc.contributor.affiliationS�nchez-Hern�ndez, P.E., Laboratorio de Inmunolog�a, Divisi�n de Disciplinas, B�sicas, Departamento de Fisiolog�a, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Zamora-Perez, A.L., Departamento de Cl�nicas Odontol�gicas Integrales, Divisi�n de Disciplinas Clinicas, Instituto de Investigacion en Odontolog�a, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Fuentes-Lerma, M., Departamento de Cl�nicas Odontol�gicas Integrales, Divisi�n de Disciplinas Clinicas, Instituto de Investigacion en Odontolog�a, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Depto. de Cl�nicas, Divisi�n de Biom�dicas e Ingenier�as, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitl�n de Morelos, Jalisco, Mexico; Robles-G�mez, C., Departamento de Cl�nicas Odontol�gicas Integrales, Divisi�n de Disciplinas Clinicas, Instituto de Investigacion en Odontolog�a, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Departamento de Cl�nicas Odontol�gicas Integrales, Divisi�n de Disciplinas Cl�nicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Mariaud-Schmidt, R.P., Departamento de Cl�nicas Odontol�gicas Integrales, Divisi�n de Disciplinas Clinicas, Instituto de Investigacion en Odontolog�a, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Guerrero-Vel�zquez, C., Departamento de Cl�nicas Odontol�gicas Integrales, Divisi�n de Disciplinas Clinicas, Instituto de Investigacion en Odontolog�a, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
dc.subject.headingDental Journals;Adolescent;Adult;Age Factors;Aggressive Periodontitis/im [Immunology];Biopsy;Chronic Periodontitis/im [Immunology];Dental Plaque Index;Female;Gingiva/ch [Chemistry];Gingiva/im [Immunology];Gingival Hemorrhage/cl [Classification];Gingival Hemorrhage/im [Immunology];Humans;Interleukin-12/an [Analysis];Interleukin-12/bl [Blood];Interleukin-18/an [Analysis];Interleukin-18/bl [Blood];Male;Middle Aged;Periodontal Attachment Loss/cl [Classification];Periodontal Attachment Loss/im [Immunology];Periodontal Index;Periodontal Pocket/cl [Classification];Periodontal Pocket/im [Immunology];Periodontium/im [Immunology];Young Adult
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