Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/42056
Title: IL-12 and IL-18 levels in serum and gingival tissue in aggressive and chronic periodontitis
Author: Sanchez-Hernandez, P.E.
Zamora-Perez, A.L.
Fuentes-Lerma, M.
Robles-Gomez, C.
Mariaud-Schmidt, R.P.
Guerrero-Velazquez, C.
Issue Date: 2011
Abstract: Objective: The aim of this study was to compare the levels of interleukin-12 (IL-12) and IL-18 in gingival tissue and serum between patients with chronic (n=18) or aggressive periodontitis (n=12) and healthy subjects (HS) (n=9). Methods: Gingival tissue biopsies and serum were obtained from all study subjects. The tissue was homogenized and cytokines IL-12 and IL-18 were quantified by enzyme-linked immunosorbent assay. Results: Interleukin-12 levels in gingival tissue were significantly higher in aggressive periodontitis patients than in HS; serum IL-12 was significantly elevated in aggressive periodontitis relative to both chronic periodontitis (CP) and HS. IL-18 levels in gingival tissue showed no significant differences between the groups. Patients with CP showed significantly elevated levels of serum IL-18 compared with HS; however, the aggressive periodontitis group showed no significant differences with either the CP group or the HS. Conclusions: Our results showed higher levels of IL-12 in gingival tissue and serum of patients with aggressive periodontitis, and IL-18 was elevated in the serum of CP patients. The patterns of IL-12 and IL-18 are different in chronic and aggressive periodontitis; this finding suggests distinctive mechanisms of immunopathogenesis between these forms of periodontitis. � 2011 John Wiley & Sons A/S.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-79957970148&partnerID=40&md5=b26c193996fa53b58221a26c035d5d8b
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=21332601
http://hdl.handle.net/20.500.12104/42056
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