Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/41873
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dc.contributor.authorRoman, S.
dc.contributor.authorJose-Abrego, A.
dc.contributor.authorFierro, N.A.
dc.contributor.authorEscobedo-Melendez, G.
dc.contributor.authorOjeda-Granados, C.
dc.contributor.authorMartinez-Lopez, E.
dc.contributor.authorPanduro-Cerda, Arturo
dc.date.accessioned2015-09-15T18:05:32Z-
dc.date.available2015-09-15T18:05:32Z-
dc.date.issued2014
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84902650882&partnerID=40&md5=5572f27a71c2aea04ae4c29dc5a6114e
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=24966588
dc.identifier.urihttp://hdl.handle.net/20.500.12104/41873-
dc.description.abstractHepatitis B virus (HBV) infection is the leading cause of severe chronic liver disease. This article provides a critical view of the importance of genomic medicine for the study of HBV infection and its clinical outcomes in Latin America. Three levels of evolutionary adaptation may correlate with the clinical outcomes of HBV infection. Infections in Latin America are predominantly of genotype H in Mexico and genotype F in Central and South America; these strains have historically circulated among the indigenous population. Both genotypes appear to be linked to a benign course of disease among the native and mestizo Mexicans and native South Americans. In contrast, genotypes F, A and D are common in acute and chronic infections among mestizos with Caucasian ancestry. Hepatocellular carcinoma is rare in Mexicans, but it has been associated with genotype F1b among Argentineans. This observation illustrates the significance of ascertaining the genetic and environmental factors involved in the development of HBV-related liver disease in Latin America, which contrast with those reported in other regions of the world. � 2014 Baishideng Publishing Group Inc. All rights reserved.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyWOS
dc.relation.isreferencedbyMEDLINE
dc.titleHepatitis B virus infection in Latin America: A genomic medicine approach
dc.typeArticle
dc.identifier.doi10.3748/wjg.v20.i23.7181
dc.relation.ispartofjournalWorld Journal of Gastroenterology
dc.relation.ispartofvolume20
dc.relation.ispartofissue23
dc.relation.ispartofpage7181
dc.relation.ispartofpage7196
dc.subject.keywordCentral America; Genomic medicine; Hepatitis B virus; Hepatitis B virus genotypes; Latin America; Mexico; South America
dc.contributor.affiliationRoman, S., Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara 'Fray Antonio Alcalde' and University of Guadalajara, Guadalajara, Jalisco 44280, Mexico; Jose-Abrego, A., Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara 'Fray Antonio Alcalde' and University of Guadalajara, Guadalajara, Jalisco 44280, Mexico; Fierro, N.A., Immunovirology Unit, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara 'Fray Antonio Alcalde' and University of Guadalajara, Guadalajara, Jalisco 44280, Mexico; Escobedo-Melendez, G., Viral Hepatitis Clinic, Pediatric Infectious Disease Unit, Department of Pediatric Hemato and Oncology, Civil Hospital of Guada 'Juan I. Menchaca' and University of Guadal, Guadalajara, Jalisco 44280, Mexico; Ojeda-Granados, C., Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara 'Fray Antonio Alcalde' and University of Guadalajara, Guadalajara, Jalisco 44280, Mexico; Martinez-Lopez, E., Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara 'Fray Antonio Alcalde' and University of Guadalajara, Guadalajara, Jalisco 44280, Mexico; Panduro, A., Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara 'Fray Antonio Alcalde' and University of Guadalajara, Guadalajara, Jalisco 44280, Mexico
dc.contributor.affiliationPanduro-Cerda, Arturo., Universidad de Guadalajara
dc.subject.headingIndex Medicus;Evolution, Molecular;Genomics/mt [Methods];Genomics;Genotype;Hepatitis B/di [Diagnosis];Hepatitis B/ep [Epidemiology];Hepatitis B/tm [Transmission];Hepatitis B/vi [Virology];Hepatitis B virus/ge [Genetics];Hepatitis B virus/py [Pathogenicity];Humans;Latin America/ep [Epidemiology];Molecular Epidemiology;Phenotype
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