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|dc.description.abstract||Genetic sex in mammals is determined by the sex chromosomal composition of the zygote. The X and Y chromosomes are responsible for numerous factors that must work in close concert for the proper development of a healthy sexual phenotype. The role of androgens in case of XY chromosomal constitution is crucial for normal male sex differentiation. The intracellular androgenic action is mediated by the androgen receptor (AR), and its impaired function leads to a myriad of syndromes with severe clinical consequences, most notably androgen insensitivity syndrome and prostate cancer. In this paper, we investigated the possibility that an alteration of the equine AR gene explains a recently described familial XY, SRY + disorder of sex development. We uncovered a transition in the first nucleotide of the AR start codon (c.1A>G). To our knowledge, this represents the first causative AR mutation described in domestic animals. It is also a rarely observed mutation in eukaryotes and is unique among the >750 entries of the human androgen receptor mutation database. In addition, we found another quiet mis- sense mutation in exon 1 (c.322C>T). Transcription of AR was confirmed by RT-PCR amplification of several exons. Translation of the full-length AR protein from the initiating GTG start codon was confirmed by Western blot using N- and C-terminal- specific antibodies. Two smaller peptides (25 and 14 amino acids long) were identified from the middle of exon 1 and across exons 5 and 6 by mass spectrometry. Based upon our experimental data and the supporting literature, it appears that the AR is expressed as a full-length protein and in a functional form, and the observed phenotype is the result of reduced AR protein expression levels. Copyright " 2011 S. Karger AG, Basel.",,,,,,"10.1159/000334049",,,"http://hdl.handle.net/20.500.12104/41813","http://www.scopus.com/inward/record.url?eid=2-s2.0-84857365898&partnerID=40&md5=6001c7ff3814f57e07b0f2916c1bfde0",,,,,,"01-mar",,"Sexual Development",,"108|
|dc.description.abstract||WOS",,,,,,"Androgen insensitivity; Androgen receptor; GTG start codon; Horse; Intersex; SRY + DSD syndrome; Testicular feminization; X chromosome",,,,,,"GTG mutation in the start codon of the androgen receptor gene in a family of horses with 64,XY disorder of sex development",,"Article" "45117","123456789/35008",,"Verduzco Chávez, Basilio Universidad de Guadalajara",,"Verduzco Chávez, Basilio Universidad de Guadalajara",,"2006",,,,,,,,,,"0185-0601","http://hdl.handle.net/20.500.12104/43338",,,"Español",,,,"4",,"Comercio exterior",,"288-299",,"56",,"CLASE",,,,,,,,"Inversiones",,,,"Evaluación sociopolítica de los proyectos de inversión en las economías emergentes",,"journalArticle" "43606","123456789/35008",,"Flores-Estrella, R., División de Matemáticas Aplicadas, IPICyT, Camino A la Presa de San José, Apartado Postal 2055, Colonia Lomas 4a Sección, San Luis-Potosí, S.L.P., Mexico; Quiroz, G., Facultad de Ingeniería Mecúnica (FIME), Universidad Autónoma de Nuevo León, FIME, Av.Universidad S/N, C.P. 66451, San-Nicolas de los Garza Nuevo-Leon, Mexico; Mendez-Acosta, H.O., Departamento de Ingeniería Química, Centro Universitario de Ciencias Exactas e Ingenierías (CUCEI), U.D.G., Boulevard Marcelino García Barragán s/n, Guadalajara, Jalisco, Mexico; Femat, R., División de Matemáticas Aplicadas, IPICyT, Camino A la Presa de San José, Apartado Postal 2055, Colonia Lomas 4a Sección, San Luis-Potosí, S.L.P., Mexico",,"Flores-Estrella, R.|
|dc.description.abstract||Femat, R.",,"2013",,"A robust H? controller has been developed to regulate the chemical oxygen demand in an anaerobic digester from the winery industry. A sensitivity analysis was performed, and the parameter set having the most significant effect on the process behavior was identified. The parameters inducing the most sensitivity in the solutions were selected as uncertain; in addition, they were related to kinetic terms and he hydrodynamic regime. Then, a control problem was formulated as robust regulation, and a controller was designed using H? theory to ensure robust stability. The actions of the H? controller are illustrated through numerical simulations. The controller was found to execute robust regulation facing parametric uncertainties and load disturbances. " 2013 American Chemical Society.|
|dc.title||H ? control of anaerobic digester for winery industry wastewater treatment|
|dc.relation.ispartofjournal||Industrial and Engineering Chemistry Research|
|dc.contributor.affiliation||, T., Departments of a Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada, Institute for Small Animal Research, Coordination Centre for Gene Conservation, Godollo, Hungary; Villagómez, D.A.F., Departments of a Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada, Departamento de Producción Animal, Universidad de Guadalajara, Zapopan, Mexico; Brewer, D., Mass Spectrometry Facility, Advanced Analysis Centre, University of Guelph, Guelph, ON, Canada; Chenier, T., Departments of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada; King, W.A., Departments of a Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada|
|Appears in Collections:||Producción científica UdeG|
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