Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/41729
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dc.contributor.authorAlcantar-Diaz, B.E.
dc.contributor.authorGomez-Meda, B.C.
dc.contributor.authorZuniga-Gonzalez, G.M.
dc.contributor.authorZamora-Perez, A.L.
dc.contributor.authorGonzalez-Cuevas, J.
dc.contributor.authorAlvarez-Rodriguez, B.A.
dc.contributor.authorSanchez-Parada, M.G.
dc.contributor.authorGarcia-Banuelos, J.J.
dc.contributor.authorArmendariz-Borunda, J.
dc.date.accessioned2015-09-15T18:02:48Z-
dc.date.available2015-09-15T18:02:48Z-
dc.date.issued2012
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84862669156&partnerID=40&md5=5b05f4cfa31adcfd0bb933a76d7151e9
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=22683486
dc.identifier.urihttp://hdl.handle.net/20.500.12104/41729-
dc.description.abstractPirfenidone is a non-steroidal antifibrotic compound that has been proposed in clinical protocols and experimental studies as a pharmacological treatment for fibroproliferative diseases. The objective of this study was to determine the genotoxicity or cytotoxicity of three doses of pirfenidone using the micronuclei test in peripheral blood erythrocytes of rodent models. Pirfenidone was administered orally to Balb-C mice for 3. days, and also was administered topically to hairless Sprague Dawley rats during the final stage of gestation. Mice were sampled every 24. h over the course of 6. days; pregnant rats were sampled every 24. h during the last 6. days of gestation, and pups were sampled at birth. Blood smears were analyzed and the frequencies of micronucleated erythrocytes (MNEs), micronucleated polychromatic erythrocytes (MNPCEs), and the proportion of polychromatic erythrocytes (PCEs), were recorded in samples from mice, pregnant rats and rat neonates. Increases in MN frequencies (p< 0.03) were noted only in the positive control groups. No genotoxic effects or decreased PCE values were observed neither in newborn rats transplacentally exposed to pirfenidone, or in two adult rodent models when pirfenidone was administered orally or topically. � 2012 Elsevier Ltd.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyMEDLINE
dc.relation.isreferencedbyWOS
dc.titleGenotoxic evaluation of pirfenidone using erythrocyte rodent micronucleus assay
dc.typeArticle
dc.identifier.doi10.1016/j.fct.2012.05.049
dc.relation.ispartofjournalFood and Chemical Toxicology
dc.relation.ispartofvolume50
dc.relation.ispartofissue8
dc.relation.ispartofpage2760
dc.relation.ispartofpage2765
dc.subject.keywordAntioxidant; DNA damage; Fibrosis; Micronuclei; Pyridone; Rodent
dc.contributor.affiliationAlc�ntar-D�az, B.E., Instituto de Biolog�a Molecular en Medicina y Terapia G�nica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico; G�mez-Meda, B.C., Instituto de Biolog�a Molecular en Medicina y Terapia G�nica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico; Z��iga-Gonz�lez, G.M., Laboratorio de Mutag�nesis, Centro de Investigaci�n Biom�dica de Occidente, Instituto Mexicano del Seguro Social, Mexico; Zamora-Perez, A.L., Instituto de Investigaci�n en Odontolog�a, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico; Gonz�lez-Cuevas, J., Instituto de Biolog�a Molecular en Medicina y Terapia G�nica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico; �lvarez-Rodr�guez, B.A., Instituto de Biolog�a Molecular en Medicina y Terapia G�nica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico; S�nchez-Parada, M.G., Instituto de Biolog�a Molecular en Medicina y Terapia G�nica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico; Garc�a-Ba�uelos, J.J., Instituto de Biolog�a Molecular en Medicina y Terapia G�nica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico; Armend�riz-Borunda, J., Instituto de Biolog�a Molecular en Medicina y Terapia G�nica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico, O.P.D. Hospital Civil de Guadalajara, Guadalajara, Jalisco, Mexico
dc.subject.headingIndex Medicus;Animals;Anti-Inflammatory Agents, Non-Steroidal/to [Toxicity];Erythrocytes/de [Drug Effects];Erythrocytes/ul [Ultrastructure];Female;Male;Mice;Mice, Inbred BALB C;Micronucleus Tests;Mutagens/to [Toxicity];Pregnancy;Pyridones/to [Toxicity];Rats;Rats, Sprague-Dawley
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