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Title: Genotoxicity produced by disease and drugs
Author: Magana, M.T.
Perea, F.J.
Gonzalez, J.R.
Ibarra, B.
Issue Date: 2007
Abstract: We analyzed 112 ?A chromosomes from the Costa Chica region, with the aim of determining the 3? haplotype (3?Hp) in Afromestizo individuals and its relationship with the reported populations. Thirty polymorphic sites were identified by sequencing and two by restriction fragment length polymorphisms. Genetic variability, genetic distances and neutrality tests were performed with the computer program Arlequin 3.0. Three groups were constructed, which we named 3kb-Hp, 330bp-Hp and 2.67kb-Hp with 32, 15 and 17 polymorphic sites respectively. In 3kb-Hp, 34 different 3? haplotypes (14 of them new) were found; the three most common were 7B1 (17.8%), 7A1 (17.0%) and 1C1 (14.3%). 330bp-Hp revealed 18 different allelic sequences; the most frequent were the 1 (AT9T5, 22.3%), 2 (AT8T5, 20.5%) and 3 (AT7T7, 20.5%). 2.67kb-Hp displayed 14 distinct haplotypes, with B1 (30.3%), A1 (28.6%) and C1 (21.4%) having the highest frequencies. The gene diversity of the Costa Chica population was only significantly different to Gambia. In the genetic distances, the p values were not significant for Vanuatu, Sumatra and Central African Republic. The neutrality tests showed that the patterns of diversity in the Costa Chica population deviate significantly from the expectations of the standard neutral model. This is the first work performed in Mexico in which the extended 3?Hp was analyzed in ?A chromosomes. The study showed clearly the presence of African and Asian genes in the Costa Chica population. " 2007 Elsevier Inc. All rights reserved.",,,,,,"10.1016/j.bcmd.2007.03.004",,,"","",,,,,,"2",,"Blood Cells, Molecules, and Diseases",,"169
WOS",,,,,,"?A globin gene haplotypes; (AT)xTy repeats; 3? haplotypes; Mexican Afromestizos; Neutrality tests",,,,,,"Genetic relationship of a Mexican Afromestizo population through the analysis of the 3? haplotype of the ? globin gene in ?A chromosomes",,"Article" "43494","123456789/35008",,,,"Barba Solano, Carlos",,"2001",,,,,,,,,,"1665-0565","",,,"Español",,,,"22",,"Espiral. Estudios sobre estado y sociedad",,"197-221",,"8",,"CLASE",,,,,,,,"Condiciones económicas",,,"El mercado de trabajo de los trabajadores no manuales de la industria electrónica de la zona metropolitana de Guadalajara","El mercado de trabajo de los trabajadores no manuales de la industria electrónica de la zona metropolitana de Guadalajara: un estudio de caso",,"journalArticle" "45083","123456789/35008",,,,,,"2002",,,,,,,,"10.1021/es022270i",,"0013-936X","","",,,,"American Chemical Society",,"7",,"Environmental science & technology",,"132A
132A",,"36",,"ChemAbsS",,,,,,,,,,,,"Budget: Fiscal Year 2003 budget",,"Journal Article" "43504","123456789/35008",,"Armendariz-Borunda, J., Institute of Molecular Biology in Medicine and Gene Therapy, CUCS, University of Guadalajara, Jal, México.",,"Armendariz-Borunda, J.",,"2002",,"Genomic medicine represents a powerful armamentarium to tackle down most of chronic diseases which have not, so far, defeated. Thus, this new and powerful biotechnologic set of weapons enable us to make use of molecular diagnostic to detect silent diseases, otherwise undetectable by conventional analysis. Moreover, elucidation of the complete and final draft of the human genome code will allow, although not in this decade, the design of specific farmaco-genetic treatments for patients on basis of their individual genetic code. Regarding new medical treatments, gene therapy as emerged as a true hope for treatment of many chronic diseases. 636 FDA-.approved clinical protocols are currently undergoing and sooner than later we ll be witness of the results",,,,,,,,,"","",,,,,,"4",,"Annals of hepatology : official journal of the Mexican Association of Hepatology",,"169
174",,"1",,"Scopus",,,,,,,,,,,,"Genomic medicine in Mexico. Applications of gene therapy for cirrhosis reversion.",,"Review" "43532","123456789/35008",,"Rossotti, A., Posgrado en Ciencias de la Tierra, UNAM, Campus Juriquilla, A.P. 1-742, 76001 Querétaro, Qro., Mexico; Ferrari, L., Centro de Geociencias, UNAM, Campus Juriquilla, A.P. 1-742, 76001 Querétaro, Qro., Mexico; López-Martinez, M., Departamento de Geología, CICESE, A.P. 2732, 22860, Ensenada, Baja California, Mexico; Rosas-Elguera, J., Centro de Ciencias de la Tierra, Universidad de Guadalajara, A.P. 4-045, 44840 Guadalajara, Jal., Mexico",,"Rossotti, A.
Ferrari, L.
Lopez-Martinez, M.
Rosas-Elguera, J.",,"2002",,"To investigate the time-space relationship between the Sierra Madre Occidental (SMO) and the Trans-Mexican Volcanic Belt (TMVB), as well as the early volcanic activity of the TMVB, a field study was carried out in the region north of Guadalajara City, along the boundary between the two volcanic provinces. Detailed field mapping at 1:50,000 scale, supported by published and new isotopic ages allow to propose a new stratigraphy (30 lithostratigraphic units) and to clarify the volcanic evolution of the region. The SMO succession is made of about 400 m of regional ash flows tuffs of early Miocene age, capped to the south by a basaltic sequence for which we obtained an 40Ar/39Ar age of 21.8 0.3 Ma. The SMO units are sub-horizontal north of García de la Cadena but dip up to 25 to the south of this town, where they are covered in unconformity by the TMVB volcanism. A gap of about 10 Ma in the volcanism is observed between the two volcanic provinces. Volcanism pertaining to the TMVB is largely bimodal and can be divided into four stages: 1) a late Miocene mafic episode; it produced the Río Santiago group that consists of a >800 m thick basaltic succession extending toward the east into the Los Altos de Jalisco; 2) a latest Miocene (7-5 Ma) silicic episode with the emplacement of domes and flows that form the Guadalajara group; 3) an early Pliocene (4.7-3.7 Ma) episode characterized by the emplacement of ignimbrites that show evidence of mingling between a mafic and a silicic magma (San Gaspar and Guadalajara ignimbrites) and alkali-basalts with an intra-plate affinity (Mirador de Ixcatán basalts); 4) a late Pliocene to Pleistocene episode with the eruption of rhyolitic domes and flows (Cerro Chicharrón group) and alkalibasalts, also showing an intra-plate affinity (Santa Rosa basalts). New K/Ar ages of 10.2 0.4 and 7.5 0.8 Ma, together with previous dates, confirm that most of the Río Santiago Group was emplaced between 11 and ?8 Ma. Its aggregate volume in the Guadalajara region is about 1,800 km3. The silicic volcanism covers more than 1,000 km2 and has an aggregate estimated volume of300 km3, which is about nine times the volume of magma extruded by the late Pleistocene La Primavera caldera. The vents of the silicic domes belonging to the Guadalajara group and Cerro Chicharrón group follow an average N-S trend, and represent the surficial expression of a long-lived silicic upper crustal chamber with the La Primavera caldera at its southern end. By contrast, the Mirador de Ixcatán and Santa Rosa alkali-basalts are associated with the PlioPleistocene WNW-ESE trending faults of the Plan de Barrancas-Santa Rosa graben and their eruption coincide with the beginning of two extensional pulses along these faults. This agrees with models suggesting that mafic volcanism preferentially erupt along arc-parallel, high strain rate faults, whereas arc-normal, low strain rate faults control the location of more differentiated lavas. Magma mixing found in the San Gaspar and Guadalajara ignimbrites suggest that the arrival of mafic magma in the upper crust during the early Pliocene extensional phase triggered these pyroclastic eruptions.",,,,,,,,,"","",,,,,,"1",,"Revista Mexicana de Ciencias Geologicas",,"1
15",,"19",,"Scopus",,,,,,"Geology; Guadalajara; Mexico; Sierra Madre Occidental; Trans-Mexican Volcanic Belt",,,,,,"Geology of the boundary between the Sierra Madre Occidental and the Trans-Mexican Volcanic Belt in the Guadalajara region, western Mexico",,"Article" "43509","123456789/35008",,"Zúñiga-González, G.M., Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada 800, Col. Independencia, C.P. 44340, Mexico; Gómez-Meda, B.C., Instituto de Biología Molecular en Medicina, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Guadalajara, Mexico; Zamora-Perez, A.L., Instituto de Investigación en Odontología, Departamento de Clínicas Odontológicas Integrales, Centro Universitario de Ciencias de la Salud, Guadalajara, Mexico; Gallegos-Arreola, M.P., Laboratorio de Genética Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Mexico",,"Zuniga-Gonzalez, G.M.
Gomez-Meda, B.C.
Zamora-Perez, A.L.
Gallegos-Arreola, M.P.",,"2009",,"In humans, DNA damage or genotoxicity may be caused by exposure to outsideagents like radiation, pesticides, combustion of hydrocarbons products as well asantineoplastic drugs. But also DNA damage could be come from inside of the body,determined mainly for excessive free radicals production generated by some diseaseprocess and that their increase exceed the natural defense systems responsible forremoving free radicals. In either case, the important thing is to identify the genotoxicityand try to protect the body, this may as simply as removing the source of exposure orprovide protection against such agents. In this chapter, we address some ways of how it has been identified genotoxiccompounds by direct analyses, basically micronucleogenics ones expressed quantitativelyby number of micronuclei in peripheral blood erythrocytes and micronucleated cells fromoral mucosa, the genotoxicity of some antineoplastic drugs as well as the identification ofsome diseases that are "genotoxic" to the individual that suffers it and that under certainconditions can also result in potentially teratogenic for children to mothers who hadsuffered some of these disorders. " 2009 Nova Science Publishers, Inc. All rights reserved.
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