Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12104/41422
Título: Extracellular adenosine in the human brain during sleep and sleep deprivation: An in vivo microdialysis study
Autor: Zeitzer, J.M.
Morales-Villagran, A.
Maidment, N.T.
Behnke, E.J.
Ackerson, L.C.
Lopez-Rodriguez, F.
Fried, I.
Engel Jr., J.
Wilson, C.L.
Fecha de publicación: 2006
Resumen: Study Objectives: To examine the pattern of extracellular adenosine in the human brain during sleep deprivation, sleep, and normal wake. Design: Following recovery from implantation of clinical depth electrodes, epilepsy patients remained awake for 40 continuous hours, followed by a recovery sleep episode. Setting: Neurology ward at UCLA Medical Center. Patients or Participants: Seven male epilepsy patients undergoing depth electrode localization of pharmacologically refractory seizures. Interventions: All subjects were implanted with depth electrodes, a subset of which were customized to contain microdialysis probes. Microdialysis samples were collected during normal sleep, sleep deprivation, and recovery sleep from human amygdalae (n=8), hippocampus (n=1), and cortex (n=1). Measurements and Results: In none of the probes did we observe an increase in extracellular adenosine during the sleep deprivation. There was a significant, though very small, diurnal oscillation (2.5%) in 5 of the 8 amygdalae. There was no effect of epileptogenicity on the pattern of extracellular adenosine. Conclusions: Our observations, along with those in animal studies, indicate that the role of extracellular adenosine in regulating sleep pressure is not a global brain phenomenon but is likely limited to specific basal forebrain areas. Thus, if energy homeostasis is a function of sleep, an increased rate of adenosine release into the extracellular milieu of the amygdala, cortex, or hippocampus is unlikely to be a marker of such a process.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-33745793420&partnerID=40&md5=04734706fe1c12573c636dbcc0619abb
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