Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/41408
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dc.contributor.authorNavarro-Hernandez, R.E.
dc.contributor.authorOregon-Romero, E.
dc.contributor.authorMercado, M.V.-D.
dc.contributor.authorRangel-Villalobos, H.
dc.contributor.authorPalafox-Sanchez, C.A.
dc.contributor.authorMuoz-Valle, J.F.
dc.date.accessioned2015-09-15T17:56:42Z-
dc.date.available2015-09-15T17:56:42Z-
dc.date.issued2009
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-68649119081&partnerID=40&md5=6f76c4f569076264b6c52d1cae8d514f
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=19597294
dc.identifier.urihttp://hdl.handle.net/20.500.12104/41408-
dc.description.abstractTo investigate the association of sICAM-1 and sVCAM-1 with ICAM1 721G>A and VCAM1 1238G>C polymorphisms and rheumatoid arthritis (RA) clinical activity, sixty RA patients and 60 healthy non-related subjects (HS) matched for age and sex were recruited. Soluble adhesion molecules were determined by ELISA technique. Rheumatoid factor (RF), C reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) were measured by routine methods. Disability and clinical activity was measured with Spanish-HAQ-DI and DAS28 scores, respectively. The ICAM1 and VCAM1 polymorphism were identified using the PCR-RFLP procedure. Inter-group comparison showed increased levels of sICAM-1 and sVCAM-1 in RA patients (284 and 481 ng/mL) versus HS (132 and 280 ng/mL); in the RA group, significant correlations between sVCAM-1 and RF (r = 0.402), ESR (r = 0.426), Spanish-HAQ-DI (r = 0.276), and DAS28 (r = 0.342) were found, whereas sICAM-1 only correlated with RF (r = 0.445). In RA patients, a significant association with the 721A allele of ICAM1 polymorphism (p = 0.04), was found. In addition, the allele impact (G/A+A/A) of this polymorphism was confirmed, (p = 0.038, OR = 2.3, C.I. 1.1-5.0). sVCAM-1 and sICAM-1 serum levels reflected the clinical status in RA, independently of the ICAM1 and VCAM1 polymorphism. However, the ICAM1 721A allele could be a genetic marker to RA susceptibility. � 2009 IOS Press and the authors. All rights reserved.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyMEDLINE
dc.relation.isreferencedbyWOS
dc.titleExpression of ICAM1 and VCAM1 serum levels in rheumatoid arthritis clinical activity. Association with genetic polymorphisms
dc.typeArticle
dc.identifier.doi10.3233/DMA-2009-0621
dc.relation.ispartofjournalDisease Markers
dc.relation.ispartofvolume26
dc.relation.ispartofissue3
dc.relation.ispartofpage119
dc.relation.ispartofpage126
dc.subject.keywordICAM-1; Polymorphism; Rheumatoid arthritis; Soluble adhesion molecules; VCAM-1
dc.contributor.affiliationNavarro-Hern�ndez, R.E., Instituto de Investigacion en Reumatologia y Del Sistema Musculo Esqueletico, Departamento de Biolog�a Molecular y Gen�mica, Universidad de Guadalajara, Mexico; Oregon-Romero, E., Instituto de Investigacion en Reumatologia y Del Sistema Musculo Esqueletico, Departamento de Biolog�a Molecular y Gen�mica, Universidad de Guadalajara, Mexico; Mercado, M.V.-D., Instituto de Investigacion en Reumatologia y Del Sistema Musculo Esqueletico, Departamento de Biolog�a Molecular y Gen�mica, Universidad de Guadalajara, Mexico; Rangel-Villalobos, H., Instituto de Investigaci�n en Gen�tica Molecular, Centro Universitario de la Ci�nega, Universidad de Guadalajara, Ocotl�n, Jalisco, Mexico; Palafox-S�nchez, C.A., Instituto de Investigacion en Reumatologia y Del Sistema Musculo Esqueletico, Departamento de Biolog�a Molecular y Gen�mica, Universidad de Guadalajara, Mexico; Muoz-Valle, J.F., Instituto de Investigacion en Reumatologia y Del Sistema Musculo Esqueletico, Departamento de Biolog�a Molecular y Gen�mica, Universidad de Guadalajara, Mexico, Insurgentes 244-1, Colonia Lomas de Atemajac, Zapopan, Jalisco, C.P. 45178, Mexico
dc.subject.headingIndex Medicus;Adult;Arthritis, Rheumatoid/bl [Blood];Arthritis, Rheumatoid/ge [Genetics];Base Sequence;Case-Control Studies;DNA Primers;Enzyme-Linked Immunosorbent Assay;Female;Humans;Intercellular Adhesion Molecule-1/bl [Blood];Intercellular Adhesion Molecule-1/ge [Genetics];Male;Middle Aged;Polymerase Chain Reaction;Polymorphism, Genetic;Polymorphism, Restriction Fragment Length;Spain;Vascular Cell Adhesion Molecule-1/bl [Blood];Vascular Cell Adhesion Molecule-1/ge [Genetics]
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