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|Title:||Expression of ICAM1 and VCAM1 serum levels in rheumatoid arthritis clinical activity. Association with genetic polymorphisms|
|Abstract:||Because (i) changes in plasma and liver mRNA of apolipoprotein (apo) AI have been observed in patients with alcoholic liver disease, (ii) apo AI mRNA can be induced in non-hepatic tissues, and (iii) apolipoproteins expression is influenced by plasma colloid osmotic pressure (PCO) and viscosity (?), we analyzed the Apo AI mRNA expression in the peripheral white blood cells (PWBC), PCO, and ? in control volunteers (C), patients with liver cirrhosis (LC), and cirrhotic patients with superimposed alcoholic hepatitis (LC+AH). We found that apo AI mRNA is expressed in the PWBC in 20% of C and it is induced 1.5 fold in 66.6% of LC and 1.95 fold in 85% of LC+AH. A significant decrease of PCO in LC and LC+AH (14.8 2.4 and 16.2 2.4 mm Hg, respectively) compared to C (27.9 2 mm Hg) was observed. By contrast, ? was mildly increased from 1.7389 0.07 in C to 1.8022 0.154 in LC and 1.9030 0.177 in LC+AH. No significant correlation was found between PCO and ? with apo AI mRNA but with lipid profile. In conclusion, apo AI mRNA expression in PWBC is associated to liver disease severity and could be an indirect indicator of alcoholic liver damage. " 2004 Elsevier B.V. All rights reserved.",,,,,,"10.1016/j.bbadis.2004.11.003",,,"http://hdl.handle.net/20.500.12104/41403","http://www.scopus.com/inward/record.url?eid=2-s2.0-20444386564&partnerID=40&md5=b70b67e2033bdaef8097164fd4db193e",,,,,,"3",,"Biochimica et Biophysica Acta - Molecular Basis of Disease",,"350|
WOS",,,,,,"Alcoholic hepatitis; Apolipoprotein AI; Gene expression; Liver cirrhosis",,,,,,"Expression of apolipoprotein AI mRNA in peripheral white blood cells of patients with alcoholic liver disease",,"Article" "43187","123456789/35008",,"Navarro-Hernández, R.E., Instituto de Investigacion en Reumatologia y Del Sistema Musculo Esqueletico, Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Mexico; Oregon-Romero, E., Instituto de Investigacion en Reumatologia y Del Sistema Musculo Esqueletico, Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Mexico; Mercado, M.V.-D., Instituto de Investigacion en Reumatologia y Del Sistema Musculo Esqueletico, Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Mexico; Rangel-Villalobos, H., Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán, Jalisco, Mexico; Palafox-Sánchez, C.A., Instituto de Investigacion en Reumatologia y Del Sistema Musculo Esqueletico, Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Mexico; Muoz-Valle, J.F., Instituto de Investigacion en Reumatologia y Del Sistema Musculo Esqueletico, Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Mexico, Insurgentes 244-1, Colonia Lomas de Atemajac, Zapopan, Jalisco, C.P. 45178, Mexico",,"Navarro-Hernandez, R.E.
Muoz-Valle, J.F.",,"2009",,"To investigate the association of sICAM-1 and sVCAM-1 with ICAM1 721G>A and VCAM1 1238G>C polymorphisms and rheumatoid arthritis (RA) clinical activity, sixty RA patients and 60 healthy non-related subjects (HS) matched for age and sex were recruited. Soluble adhesion molecules were determined by ELISA technique. Rheumatoid factor (RF), C reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) were measured by routine methods. Disability and clinical activity was measured with Spanish-HAQ-DI and DAS28 scores, respectively. The ICAM1 and VCAM1 polymorphism were identified using the PCR-RFLP procedure. Inter-group comparison showed increased levels of sICAM-1 and sVCAM-1 in RA patients (284 and 481 ng/mL) versus HS (132 and 280 ng/mL); in the RA group, significant correlations between sVCAM-1 and RF (r = 0.402), ESR (r = 0.426), Spanish-HAQ-DI (r = 0.276), and DAS28 (r = 0.342) were found, whereas sICAM-1 only correlated with RF (r = 0.445). In RA patients, a significant association with the 721A allele of ICAM1 polymorphism (p = 0.04), was found. In addition, the allele impact (G/A+A/A) of this polymorphism was confirmed, (p = 0.038, OR = 2.3, C.I. 1.1-5.0). sVCAM-1 and sICAM-1 serum levels reflected the clinical status in RA, independently of the ICAM1 and VCAM1 polymorphism. However, the ICAM1 721A allele could be a genetic marker to RA susceptibility. " 2009 IOS Press and the authors. All rights reserved.
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