Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/41053
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRamirez-Ramirez, R.
dc.contributor.authorGutierrez-Angulo, M.
dc.contributor.authorMagana, M.T.
dc.contributor.authorMoreno-Ortiz, J.M.
dc.contributor.authorPartida-Perez, M.
dc.contributor.authorMuniz-Mendoza, R.
dc.contributor.authorPeregrina-Sandoval, J.
dc.contributor.authorSuarez-Villanueva, A.S.
dc.contributor.authorCenteno-Flores, M.
dc.contributor.authorMaciel-Gutierrez, V.M.
dc.contributor.authorCabrales-Vazquez, E.
dc.contributor.authorAyala-Madrigal, M.L.
dc.date.accessioned2015-09-15T17:49:50Z-
dc.date.available2015-09-15T17:49:50Z-
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/20.500.12104/41053-
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84921931342&partnerID=40&md5=ee99e6dd89c6921eba6ae208c9e4a34e
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25729968
dc.description.abstractThe ZNF217 gene, a potential oncogene amplified and overexpressed in several cancers including colorectal cancer (CRC), acts as a transcription factor that activates or represses target genes. The polymorphisms rs16998248 (T>A) and rs35720349 (C>T) in coronary artery disease have been associated with reduced expression of ZNF217. In this study, we analyzed the 2 polymorphisms in Mexican patients with CRC. Genotyping of rs16998248 and rs35720349 sites was performed by polymerase chain reaction-restriction fragment length polymorphism in 203 Mexican Mestizos, 101 CRC patients, and 102 healthy blood donors. Although no statistical differences regarding genotype and allele frequencies of ZNF217 polymorphisms were observed (P > 0.05), linkage disequilibrium was significant in CRC patients (r2 = 0.39, P < 0.0001), as a result of reduced AC haplotype frequency. Thus, the AC haplotype may protect against CRC. FUNPEC-RP.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyWOS
dc.relation.isreferencedbyMEDLINE
dc.titleEffect of ZNF217 gene polymorphisms on colorectal cancer development in a Mexican population
dc.typeArticle
dc.identifier.doi10.4238/2015.January.23.9
dc.relation.ispartofjournalGenetics and Molecular Research
dc.relation.ispartofvolume14
dc.relation.ispartofissue1
dc.relation.ispartofpage362
dc.relation.ispartofpage367
dc.subject.keywordColorectal cancer; rs16998248; rs35720349; ZNF217 / Index Medicus
dc.contributor.affiliationRamírez-Ramírez, R., Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico; Gutiérrez-Angulo, M., Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico, Departamento de Clínicas, CUAltos, Universidad de GuadalajaraJalisco, Mexico; Magaña, M.T., División de Genética, CIBO, IMSSGuadalajara, Jalisco, Mexico; Moreno-Ortiz, J.M., Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico; Partida-Pérez, M., Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico; Muñiz-Mendoza, R., Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico; Peregrina-Sandoval, J., Laboratorio de Inmunobiología, CUCBA, Universidad de GuadalajaraZapopan, Jalisco, Mexico; Suárez-Villanueva, A.S., Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico; Centeno-Flores, M., Servicio de Colon y Recto, Juan I. Menchaca Hospital CivilGuadalajara, Jalisco, Mexico; Maciel-Gutiérrez, V.M., Servicio de Colon y Recto, Juan I. Menchaca Hospital CivilGuadalajara, Jalisco, Mexico; Cabrales-Vazquez, E., Servicio de Oncología Fray Antonio Alcalde Hospital CivilGuadalajara, Jalisco, Mexico; Ayala-Madrigal, M.L., Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de GuadalajaraGuadalajara, Jalisco, Mexico
Appears in Collections:Producción científica UdeG

Files in This Item:
There are no files associated with this item.


Items in RIUdeG are protected by copyright, with all rights reserved, unless otherwise indicated.