Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/41030
Title: Effect of the nutritional recovery on the concentration of Interleukin-2 in severely malnourished children [Efecto de la recuperación nutricia sobre la concentración de Interleucina-2 en niños con desnutrición grave]
Author: Reed, C.
Fofanov, V.
Putonti, C.
Chumakov, S.
Slezak, T.
Fofanov, Y.
Issue Date: 2007
Abstract: Motivation: Genomic-based methods have significant potential for fast and accurate identification of organisms or even genes of interest in complex environmental samples (air, water, soil, food, etc.), especially when isolation of the target organism cannot be performed by a variety of reasons. Despite this potential, the presence of the unknown, variable and usually large quantities of background DNA can cause interference resulting in false positive outcomes. Results: In order to estimate how the genomic diversity of the background (total length of all of the different genomes present in the background), target length and target mutation rate affect the probability of misidentifications, we introduce a mathematical definition for the quality of an individual signature in the presence of a background based on its length and number of mismatches needed to transform the signature into the closest subsequence present in the background. This definition, in conjunction with a probabilistic framework, allows one to predict the minimal signature length required to identify the target in the presence of different sizes of backgrounds and the effect of the target's mutation rate on the quality of its identification. The model assumptions and predictions were validated using both Monte Carlo simulations and real genomic data examples. The proposed model can be used to determine appropriate signature lengths for various combinations of target and background genome sizes. It also predicted that any genomic signatures will be unable to identify target if its mutation rate is > 5%. " The Author 2007. Published by Oxford University Press. All rights reserved.",,,,,,"10.1093/bioinformatics/btm420",,,"http://hdl.handle.net/20.500.12104/41030","http://www.scopus.com/inward/record.url?eid=2-s2.0-35748932362&partnerID=40&md5=51863ad63932d493f2e22d851498f523",,,,,,"20",,"Bioinformatics",,"2665
2671",,"23",,"Scopus
WOS",,,,,,,,,,,,"Effect of the mutation rate and background size on the quality of pathogen identification",,"Article" "42810","123456789/35008",,"Vásquez-Garibay, E., Instituto de Nutrición Humana and Laboratorio de Inmunología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Unidad de Estudios de Nutrición Infantil, Hospital Civil de Guadalajara, Dr. Juan I. Menchaca, Unidad de Patología Clínica AC, Guadalajara, Jalisco, Mexico; Stein, K., Instituto de Nutrición Humana and Laboratorio de Inmunología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Unidad de Estudios de Nutrición Infantil, Hospital Civil de Guadalajara, Dr. Juan I. Menchaca, Unidad de Patología Clínica AC, Guadalajara, Jalisco, Mexico; Méndez-Estrada, C., Instituto de Nutrición Humana and Laboratorio de Inmunología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Unidad de Estudios de Nutrición Infantil, Hospital Civil de Guadalajara, Dr. Juan I. Menchaca, Unidad de Patología Clínica AC, Guadalajara, Jalisco, Mexico; Pérez-Becerra, E., Instituto de Nutrición Humana and Laboratorio de Inmunología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Unidad de Estudios de Nutrición Infantil, Hospital Civil de Guadalajara, Dr. Juan I. Menchaca, Unidad de Patología Clínica AC, Guadalajara, Jalisco, Mexico; Romero-Velarde, E., Instituto de Nutrición Humana and Laboratorio de Inmunología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Unidad de Estudios de Nutrición Infantil, Hospital Civil de Guadalajara, Dr. Juan I. Menchaca, Unidad de Patología Clínica AC, Guadalajara, Jalisco, Mexico; Gutiérrez, I.I., Instituto de Nutrición Humana and Laboratorio de Inmunología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Unidad de Estudios de Nutrición Infantil, Hospital Civil de Guadalajara, Dr. Juan I. Menchaca, Unidad de Patología Clínica AC, Guadalajara, Jalisco, Mexico; Ortega, M.A.O., Instituto de Nutrición Humana and Laboratorio de Inmunología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Unidad de Estudios de Nutrición Infantil, Hospital Civil de Guadalajara, Dr. Juan I. Menchaca, Unidad de Patología Clínica AC, Guadalajara, Jalisco, Mexico; Iglesias, T.G., Instituto de Nutrición Humana and Laboratorio de Inmunología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Unidad de Estudios de Nutrición Infantil, Hospital Civil de Guadalajara, Dr. Juan I. Menchaca, Unidad de Patología Clínica AC, Guadalajara, Jalisco, Mexico",,"Vasquez-Garibay, E.
Stein, K.
Mendez-Estrada, C.
Perez-Becerra, E.
Romero-Velarde, E.
Gutierrez, I.I.
Ortega, M.A.O.
Iglesias, T.G.",,"2008",,"The severely malnourished child has dysfunction of the immune response that may increase the risk of morbidity or mortality due to infectious diseases, therefore, the purpose of this study was to demonstrate the effect of intensive nutritional support on the cellular and serum concentration of IL-2 and CD4+, as well as CD8+ T cells in children with severe protein energy malnutrition. A clinical assay was carried out in a tertiary care hospital. 10 severely malnourished children < 48 months of age who received formula without lactose via enteral feeding for two weeks and ad libitum for an additional two weeks were included. Cellular and serum concentrations of IL- 2 and the subpopulation of CD4+ and CD8+ were obtained. A control group (n = 13) was included. A paired student t test for initial-final determinations and the Mann-Whitney Test for comparison with control group were used, and null hypothesis was rejected with a p value < 0,05. There was a noteworthy increase in the comparison between the initial vs. final percentage of the cellular expression of IL-2 (p < 0,001) and in the serum concentration of IL-2 (p = 0,001). Therefore, four weeks of nutritional recovery significantly restored the production of IL-2, independently of the nutrients involved in the process, although, the rate of restoration seems to depend on the severity of the children primary PEM. " 2009 Archivos Latinoamericanos de Nutrición.
URI: http://hdl.handle.net/20.500.12104/41031
http://www.scopus.com/inward/record.url?eid=2-s2.0-60549110498&partnerID=40&md5=0960b88b2042ae04ceb3c46735ded87c
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