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|dc.description.abstract||Background: Angiotensin-receptor blockers (ARBs) blunt progression of advanced diabetic nephropathy, but their long-term renal effects in other patients are not clear. Objective: To examine the long-term renal effects of telmisartan versus placebo in adults at high vascular risk. Design: Randomized trial. Patients were randomly assigned by a central automated system between November 2001 and May 2004 and were followed until March 2008. Participants and investigators were blinded to intervention status. Setting: Multicenter, multinational study. Patients: 5927 adults with known cardiovascular disease or diabetes with end-organ damage but without macroalbuminuria or heart failure who cannot tolerate angiotensin-converting enzyme inhibitors. Intervention: Telmisartan, 80 mg/d (n = 2954), or matching placebo (n = 2972) plus standard treatment for a mean of 56 months. Measurements: Composite renal outcome of dialysis or doubling of serum creatinine, changes in estimated glomerular filtration rate (GFR), and changes in albuminuria. Results: No important difference was found in the composite renal outcome with telmisartan (58 patients [1.96%]) versus placebo (46 patients [1.55%]) (hazard ratio, 1.29 [95% CI, 0.87 to 1.89]; P = 0.20). Among the telmisartan and placebo groups, 7 and 10 patients had dialysis and 56 and 36 patients had doubling of serum creatinine, respectively (hazard ratio, 1.59 [CI, 1.04 to 2.41]; P = 0.031). Albuminuria increased less with telmisartan than with placebo (32% [CI, 23% to 41%] vs. 63% [CI, 52% to 76%]; P = 0.001). Decreases in estimated GFR were greater with telmisartan than with placebo (mean change in estimated GFR, -3.2 mL/min per 1.73 m2 [SD, 18.3] vs. -0.26 mL/min per 1.73 m2 [SD, 18.0]; P < 0.001). Limitation: Only 17 participants had dialysis. Conclusion: In adults with vascular disease but without macroalbuminuria, the effects of telmisartan on major renal outcomes were similar to those of placebo. Primary Funding Source: Boehringer Ingelheim. " 2009 American College of Physicians.",,,,,,,,,"http://hdl.handle.net/20.500.12104/41020","http://www.scopus.com/inward/record.url?eid=2-s2.0-67650070753&partnerID=40&md5=65c169e732d05dd4c701e39f67193548",,,,,,"1",,"Annals of Internal Medicine",,"1|
|dc.description.abstract||WOS",,,,,,,,,,,,"Effect of telmisartan on renal outcomes: A randomized trial",,"Article" "42806","123456789/35008",,"Corona Berkin, Sarah Universidad de Guadalajara",,"Corona Berkin, Sarah Universidad de Guadalajara",,"2006",,,,,,,,,,"0188-8900","http://hdl.handle.net/20.500.12104/41027",,,"Español",,,,"32",,"Fuentes humanísticas",,"jul-17",,,,"CLASE",,,,,,,,"Investigación educativa",,,,"El contexto escolar de la lectura en una escuela wixárika",,"journalArticle" "42808","123456789/35008",,"Michel, C.R., Departamento de Física CUCEI, Universidad de Guadalajara, Boulevard Marcelino García Barragan 1421, 44410 Guadalajara, Jalisco, Mexico; Martínez-Preciado, A.H., Departamento de Física CUCEI, Universidad de Guadalajara, Boulevard Marcelino García Barragan 1421, 44410 Guadalajara, Jalisco, Mexico; Morán-Lázaro, J.P., Departamento de Física CUCEI, Universidad de Guadalajara, Boulevard Marcelino García Barragan 1421, 44410 Guadalajara, Jalisco, Mexico",,"Michel, C.R.|
|dc.description.abstract||Moran-Lazaro, J.P.",,"2009",,"CoSb2O6 with trirutile-type structure was prepared by a colloidal method using cobalt nitrate hydrate, antimony trichloride, ethylenediamine and ethyl alcohol. To obtain a precursor material, microwave radiation was applied during the evaporation process. The thermal decomposition of the precursor powder at 600 °C produced single-phase polycrystalline CoSb2O6. By scanning electron microscopy a widespread formation of microcolumns, having a length in the range of 6-18 ?m, and an average diameter of 2.5 ?m were observed. The gas sensing properties of CoSb2O6 thick films was evaluated by measuring the transient response of the magnitude of the impedance (|Z|) in air, CO2 and O2. This characterization was made at 100 Hz, 1 kHz and 100 kHz (400 °C). The results indicated that increasing the frequency, smaller |Z| values were registered. However, a lot more uniform and noise-free response during the detection of these gases was obtained. Polarization curves demonstrated that CoSb2O6 responds quantitatively to changes in the CO2 concentration. However, in O2 this behavior was not observed. " 2009 Elsevier B.V. All rights reserved.|
|dc.title||Effect of the frequency on the gas sensing response of CoSb2O6 prepared by a colloidal method|
|dc.relation.ispartofjournal||Sensors and Actuators, B: Chemical|
|dc.subject.keyword||Colloidal synthesis; CoSb2O6 microcolumns; Electron microscopy; Gas sensor; Impedance measurements|
|dc.contributor.affiliation||Mann, J.F.E., Schwabing General Hospital, KfH Kidney Center, Ludwig Maximilians University, Kolner Platz 1, DE-80804 Munich, Germany; Schmieder, R.E., Department of Nephrology and Hypertension, Friedrich Alexander University, DE-91054 Erlangen, Germany; Dyal, L., Population Health Research Institute, McMaster University, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada; McQueen, M.J., Pathology and Molecular Medicine, McMaster University and Population Health Research Institute, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada; Schumacher, H., Boehringer Ingelheim, DE-55091 Ingelheim, Germany; Pogue, J., Population Health Research Institute, McMaster University, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada; Wang, X., Beijing Hypertension League Institute, Beijing, China; Probstfield, J.L., Department of Medicine, University of Washington, Seattle, WA, United States; Avezum, A., Dante Pazzanese Institute of Cardiology, São Paulo, Brazil; Cardona-Munoz, E., Department of Physiology, University of Guadalajara, Guadalajara, Mexico; Dagenais, G.R., Institute of Cardiology and Pneumology, Laval University and Hospital, Quebec, QC, Canada; Diaz, R., Department of Medicine, University of Buenos Aires, Buenos Aires, Argentina; Fodor, G., Heart Institute, University of Ottawa, Ottawa, ON, Canada; Maillon, J.M., University of Grenoble, Grenoble, France; Rydén, L., Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Yu, C.M.; Teo, K.K., Population Health Research Institute, McMaster University, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada; Yusuf, S., Population Health Research Institute, McMaster University, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada|
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