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Title: Differential impact of hyperinsulinemia on left ventricular function in hypertense subjects [Impacto de la hiperinsulinemia sobre la función del ventrículo izquierdo en sujetos hipertensos]
Author: De Tomasi, E.B.
Juarez, J.
Issue Date: 2011
Abstract: The aim of the present study was to assess the effect of chronic naltrexone treatment on daily patterns of food intake in food-deprived and free-feeding rats. In experiment 1, Wistar male rats had continuous access to food and water, while in experiment 2 they were deprived of food for 12 h/day. Animals in both experiments were studied as follows: a baseline period (7 days), followed by a treatment period (14 days) with either saline or naltrexone at 10 mg/kg/day. Finally, a post-treatment period (7 days) was assessed. Food and water consumption were measured every 2 h after the naltrexone or saline injection for 12 h and once more 12 h later. Experiment 1: Food intake was higher in the naltrexone group 10 h after injection. Total food intake and body weight gain were higher in the naltrexone group than in the saline group in the second week of treatment and in the post-treatment period. Experiment 2: The overeating observed in the saline group in the hours following the 12 h of the food deprivation period was suppressed by naltrexone, though total daily food intake was not affected. Body weight gain was initially reduced by naltrexone, but a rebound effect was observed during the post-treatment period in the naltrexone group. Naltrexone produced a differential effect on food intake and body weight that depended on the rats' food deprivation status. These results could be explained in terms of opioid receptor up-regulation that enhances the rewarding effects of food or by naltrexone-produced changes in palatability. " 2010 Elsevier B.V. All rights reserved.",,,,,,"10.1016/j.ejphar.2010.10.029",,,"","",,,,,,"1",,"European Journal of Pharmacology",,"261
WOS",,,,"Index Medicus;Animals;Body Weight/de [Drug Effects];Drinking/de [Drug Effects];Drug Administration Schedule;Eating/de [Drug Effects];Food Deprivation;Male;Naltrexone/ad [Administration & Dosage];Naltrexone/pd [Pharmacology];Narcotic Antagonists/ad [Administration & Dosage];Narcotic Antagonists/pd [Pharmacology];Rats;Rats, Wistar",,"Alimentary behaviour; Body weight; Food intake; Naltrexone; Opioid antagonist; Water consumption",,,,,,"Differential effects of chronic naltrexone treatment on food intake patterns and body weight in rats depend on their food deprivation status",,"Article" "42429","123456789/35008",,"Muñoz, E.G.C., Centro Universitario de Ciencias de la Salud, 44320, Guadalajara, Mexico; González, S.P., Universidad de Guadalajara, Guadalajara, Mexico; Sutto, S.T., Universidad de Guadalajara, Guadalajara, Mexico; Benavides, L.G., Universidad de Guadalajara, Guadalajara, Mexico; Muller, D.C., Universidad de Guadalajara, Guadalajara, Mexico; Miranda Díaz, A.G., Universidad de Guadalajara, Guadalajara, Mexico",,"Munoz, E.G.C.
Gonzalez, S.P.
Sutto, S.T.
Benavides, L.G.
Muller, D.C.
Miranda Diaz, A.G.",,"2009",,"Introduction: Hyperinsulinemia associated with systemic hypertension activates pro-inflammatory processes and deteriorates ventricular function. Objective: To determine the effect of hyperinsulinemia on left ventricular mass and function in non-diabetic men and women with systemic hypertension. Methods: 52 patients aged 30-65, with a normal glucose tolerance test, were divided into groups according to their glucose/insulin ratio (rG/I): Group 1, hyperinsulinemic (rG/I < 1.6); Group 2, normoinsulinemic (rG/I >1.6). A complete medical history, lab tests, ECG and a cardiac echo-Doppler were performed. Results: There were no significant differences between groups concerning: age, glucose levels or blood pressure, but significant differences were found in insulin levels (32.5 vs. 8.78 mU/ml), ventricular mass (131.6 vs. 92.7 g/m2), left ventricular ejection fraction (LVEF) (73.5% vs. 69.3%), body mass index (31.2 vs. 29), mitral E/A ratio (0.92 vs. 1.35), left ventricular (LV) isovolumetric relaxation time (126.3 vs. 61 ms) and ventricular hemipressure (T1/2; 206 vs. 244.4 ms). Hyperinsulinemic women had greater insulin levels than men at 60' (12.5 vs. 6.7 times), rG/I of (0.54 vs. 0.99), LV mass (61.4% vs. 30.7%) and LV diastolic dysfuntion, E/A (0.87 vs. 0.93) and T1/2 (191.7 vs. 220.3 ms). Conclusions: Hyperinsulinemia increases left ventricular mass and impairs its diastolic function in non-diabetic hypertensive men and women, and to a greater extent in women. Copyrigth " Sociedad Iberoamericana de Información Científica (SIIC), 2009.
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