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|Title:||Neurological involvement in rheumatoid arthritis|
|Abstract:||Dopaminergic activity in the Nucleus Accumbens has been strongly implicated in the motor hyperactivity associated with Attention deficit hyperactivity disorder. Dopaminergic and glutamatergic terminals converge on the dendritic spines of medium spiny neurons of the nucleus accumbens core, which modulate the excitatory glutamatergic activity. In this work, a Golgi study was carried out to investigate the effects of dopamine depletion on the cytoarchitecture of dendritic spines of nucleus accumbens core medium spiny neurons. The dopaminergic system of newborn male rats was lesioned intracisternally by using 6-hydroxydopamine, and subsequently, the motor activity, spine density, and the proportion of thin, stubby, mushroom, wide, branched, and double spines was compared to those in control and intact animals. Motor activity was significantly increased in the dopamine-depleted animals and while the spine density was reduced, there was no change in the proportion of the specific types of spines. Larger thin spines were observed in the dopamine-depleted animals. Indeed, dopamine depletion may lead to spine retraction due to the disregulation of spine development, and/or an increase in glutamatergic activity. The enlargement of thin spines may suggest a compensatory mechanism to increase the efficiency of synaptic inputs in response to a decrease in spines number. Together, the present findings suggest an alteration to the excitatory/inhibitory balance on dendritic spines of medium spiny neurons of the nucleus accumbens core in hyperactive juvenile rats following early dopamine depletion. " 2010 ISDN.",,,,,,"10.1016/j.ijdevneu.2010.06.005",,,"http://hdl.handle.net/20.500.12104/40464","http://www.scopus.com/inward/record.url?eid=2-s2.0-77955423280&partnerID=40&md5=fc012eb253b0acfa5c680a88cc56d2c3",,,,,,"6",,"International Journal of Developmental Neuroscience",,"475|
WOS",,,,,,"6-Hydroxydopamine; Attention deficit hyperactivity disorder; Corpus striatum; Dendritic spines; Dopamine; Nucleus accumbens",,,,,,"Cytoarchitectural impairments in the medium spiny neurons of the Nucleus Accumbens core of hyperactive juvenile rats",,"Article" "42294","123456789/35008",,,"Martínez, Héctor",,"1999",,,,,,,,,,"0185-4534",,"http://hdl.handle.net/20.500.12104/40515",,"Español",,,,"3",,"Revista mexicana de análisis de la conducta",,"297-320",,"25",,"CLASE",,,,,,,,"Psicología experimental",,"Efectos del entrenamiento concurrente en dos relaciones sobre las ejecuciones de sujetos humanos en una tarea de discriminación condicional",,,,"journalArticle", "44867","123456789/35008",,"Ramos-Remus, C., Unidad de Investigación en Enfermedades Crónico-Degenerativas, Colomos 2292, Providencia, Guadalajara, 44620, Mexico, Hospital General Regional 45, Instituto Mexicano del Seguro Social, Guadalajara, Mexico; Duran-Barragan, S., Unidad de Investigación en Enfermedades Crónico-Degenerativas, Colomos 2292, Providencia, Guadalajara, 44620, Mexico, Centro Universitario del Sur, Universidad de Guadalajara, Cd Guzma?, Mexico",,"Ramos-Remus, C.
Duran-Barragan, S.",,"2010",,"Joints but specifically the synovial is the most important target in rheumatoid arthritis (RA) yet the disease is a systemic inflammatory disorder where extraarticular manifestations are common. Among extraarticular organs and systems affected by RA, central and peripheral nervous system involvement is frequent and associated with significant morbidity and, in some cases, reduced life span. It may produce a myriad of symptoms and signs ranging from subtle numbness in a hand, to quadriparesis and sudden death. Centrol and peripheral neurologic damage may arise from structural damage produced by RA in diarthroidal joints, by the systemic inflammatory process of the disease itself or by the drugs used to treat it. Neurologic syndromes in these patients may appear suddenly or developed slowly through months, and emerge early or after years of having RA. Neurologic manifestations may be easily overlooked or incorrectly assigned to peripheral arthritis unless the attending physician is aware of these complications. In this article, we review neurologic involvement in RA patients with emphasis on clinical approach for early detection. " 2010 Bentham Science Publishers Ltd.
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