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Title: CKD in disadvantaged populations
Author: Leon-Jimenez, C.
Chiquete, E.
Cantu, C.
Miramontes-Saldana, M.J.
Andrade-Ramos, M.A.
Ruiz-Sandoval, J.L.
Issue Date: 2010
Abstract: Some neuroprotective agents have shown benefits in animal models, but disappointing results in humans. Citicoline is used in several countries as coadjuvant treatment in acute ischemic stroke (AIS) patients; however, there are no retrospective postmarketing surveillances on the experience of citicoline in Mexico. The aim of this study was to evaluate the correlation between citicoline exposure and functional outcome at discharge and at 30 and 90 days post-stroke, in a retrospective case-control design on systematic descriptive databases from three referral hospitals. Clinical records of 173 consecutively registered patients were analyzed, 86 of whom were treated with citicoline within the first 48 h after AIS and the remaining 87 were untreated, randomly selected controls matched for age ( 5 years), gender and NIHSS ( 1 point) at hospital admission. Pretreatment conditions were similar between groups. Compared with controls, exposure to citicoline was associated with a significantly lower 30-day mean and median modified Rankin score (in both, P < 0.05). After paired multivariate analyses (controlled for NIHSS, age, gender, hospital arrival in < 24 h, thrombolysis and comorbidities) citicoline was independently associated with a lower 90-day mortality risk (P = 0.047) and with fewer in-hospital complications (mainly infections and sepsis, P = 0.001). In this observational study, citicoline use was associated with a better functional status and lower rates of short-term mortality, possibly due to fewer in-hospital systemic complications. The putative benefits should be interpreted as clinical associations, since this is not a randomized, controlled clinical trial. " 2010 Prous Science, S.A.U. or its licensors.",,,,,,"10.1358/mf.2010.32.5.1465004",,,"","",,,,,,"5",,"Methods and Findings in Experimental and Clinical Pharmacology",,"325
WOS",,,,,,,,,,,,"Citicoline for acute ischemic stroke in mexican hospitals: A retrospective postmarketing analysis",,"Article" "41861","123456789/35008",,,,"Moya-Raygoza,Gustavo
Nault,Lowell R.",,"2000",,,,,,,,"doi: 10.1603/0013-8746(2000)0930929:OMBDQH]2.0.CO;2; 15",,"0013-8746","","[0929:OMBDQH]2.0.CO;2",,,,"Entomological Society of America",,"4",,"Annals of the Entomological Society of America",,"929
940",,"93",,"BioOne",,,,,,,,,,,,"Obligatory Mutualism Between Dalbulus quinquenotatus (Homoptera: Cicadellidae) and Attendant Ants",,"Journal Article" "41862","123456789/35008",,"Arias, Patricia Universidad de Guadalajara",,"Arias, Patricia Universidad de Guadalajara",,"2003",,,,,,,,,,"1405-1117","",,,"Español",,,,"17",,"Estudios del hombre",,"15-46",,,,"CLASE",,,,,,,,"Sociología rural",,,,"Diversidad rural y relaciones de género en México, ayer y hoy",,"journalArticle" "41863","123456789/35008",,"Vázquez, M.I.M., Department of Pacific Studies, University of Guadalajara, Mexico",,"Vazquez, M.I.M.",,"2014",,"[No abstract available]",,,,,,,,,"","",,,,,,,,"Transnational Faiths: Latin-American Immigrants and their Religions in Japan",,"107
127",,,,"Scopus",,,,,,,,,,,,"Citizenship of god: Female sex workers and the Roman Catholic Church's advocacy for human rights",,"Book Chapter" "41864","123456789/35008",,"García-García, G., Nephrology Service, Hospital Civil de Guadalajara, University of Guadalajara Health Sciences CenterGuadalajara, Mexico; Jha, V., Postgraduate Institute of Medical Education and ResearchChandigarh, India, George Institute for Global HealthNew Delhi, India, University of OxfordOxford, United Kingdom; Li, P.K.T.; Couser, W.G.; Erk, T.; Zakharova, E.; Segantini, L.; Shay, P.; Riella, M.C.; Osafo, C.; Dupuis, S.; Kernahan, C.",,"García-García, G.
Jha, V.
Li, P.K.T.
Couser, W.G.
Erk, T.
Zakharova, E.
Segantini, L.
Shay, P.
Riella, M.C.
Osafo, C.
Dupuis, S.
Kernahan, C.",,"2015",,"The increased burden of CKD in disadvantaged populations is due to both global factors and populationspecific issues. Low socioeconomic status and poor access to care contribute to health care disparities, and exacerbate the negative effects of genetic or biologic predisposition. Provision of appropriate renal care to these populations requires a two-pronged approach: expanding the reach of dialysis through development of low-cost alternatives that can be practiced in remote locations, and implementation and evaluation of costeffective prevention strategies. Kidney transplantation should be promoted by expanding deceased donor transplant programs and use of inexpensive, generic immunosuppressive drugs. The message of WKD 2015 is that a concerted attack against the diseases that lead to ESRD, by increasing community outreach, better education, improved economic opportunity, and access to preventive medicine for those at highest risk, could end the unacceptable relationship between CKD and disadvantage in these communities. " 2015 S. Karger AG, Basel.
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