Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/39787
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dc.contributor.authorJung, H.
dc.contributor.authorGonzalez, H.
dc.contributor.authorRodriguez, J.M.
dc.date.accessioned2015-09-15T17:25:50Z-
dc.date.available2015-09-15T17:25:50Z-
dc.date.issued1993
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-0027263110&partnerID=40&md5=eb239ac6e98dda53e7e6ae9ae696ad7f
dc.identifier.urihttp://hdl.handle.net/20.500.12104/39787-
dc.description.abstractThe USP dissolution test was used to select seven products with a wide range of dissolution characteristics for in vivo examination. The bioequivalence of seven (500 mg) products was evaluated in two crossover urinary excretion experiments. In each study three products were compared with the innovator product (Negram-Winthrop-Breon) in 12 subjects according to a 4x4 latin square design. Significantly different, lower bioavailability was observed in two products in relation to that of the innovator product. Linear in vitro-in vivo correlations were found between the cumulative amount excreted at 24 h and the log of the amount dissolved at 30 min and between log of the cumulative amount excreted up to 24 h and the log of the amount dissolved at 45 min.
dc.relation.isreferencedbyScopus
dc.titleBioequivalence study of nalidixic acid tablets: In vitro-in vivo correlation
dc.typeArticle
dc.relation.ispartofjournalBiopharmaceutics and Drug Disposition
dc.relation.ispartofvolume14
dc.relation.ispartofissue5
dc.relation.ispartofpage381
dc.relation.ispartofpage388
dc.subject.keywordBioequivalence; In vitro-in vivo correlations; Nalidixic acid; USP dissolution test
dc.contributor.affiliationJung, H., Universidad de Guadalajara, Guadalajara, Jal, Mexico; Gonzalez, H., Universidad de Guadalajara, Guadalajara, Jal, Mexico; Rodriguez, J.M., Universidad de Guadalajara, Guadalajara, Jal, Mexico
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