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Title: Assessment of five thrombophilic gene polymorphisms in couples with habitual abortion [Evaluación de cinco polimorfismos de genes trombofZapotitlánlicos en parejas con aborto habitual]
Author: Quintero-Ramos, A.
Valdez-Velazquez, L.L.
Hernandez, G.
Baltazar, L.M.
Padilla-Gutierrez, J.R.
Valle, Y.
Rodarte, K.
Ortiz, R.
Ortiz-Aranda, M.
Olivares, N.
Rivas, F.
Issue Date: 2006
Abstract: An association between thrombophilic genes and obstetric conditions with early pregnancy termination has been previously proposed. In the present study we attempted to evaluate the possible association between thrombophilic genetic polymorphisms and habitual abortion (HA). Samples from two groups of volunteers were analyzed. The experimental group (n>100) was conformed by women attending the Centro Medico de Occidente, IMSS and their male couples, with a reproductive history of at least three miscarriages. The reference group (n>200) was composed by male and female healthy adults living in the state of Jalisco, Mexico. DNA was extracted from peripheral blood, and polymorphisms FII G20210A , FV G1691A, MTHFR C677T, ECA I/D y TNF G-308A were typed by PCR-RFLP or -SSP. Genotype proportions in the reference group were in agreement with the Hardy-Weinberg expectations. Allele, genotype, and phenotype proportion inter-group comparisons did not show statistically significant differences. The present results could not demonstrate that thrombophilic polymorphisms constitute risk factors for HA in Jalisco.
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