Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/39155
Title: Accumulation of exogenous amyloid- Beta peptide in hippocampal mitochondria causes their dysfunction: A protective role for melatonin
Author: Manero, O.
Perez-Lopez, J.H.
Escalante, J.I.
Puig, J.E.
Bautista, F.
Issue Date: 2007
Abstract: In this paper, a set of constitutive relationships arising from the coupling of stress with concentration, are derived using the extended irreversible thermodynamics formalism. In complex fluids that present flow-induced changes in their internal structure, the stress constitutive equation is coupled to an evolution equation of a scalar representing the flow-induced modifications in the internal structure of the fluid, and to the constitutive equation for the mass flux. In particular, the generalization of a simple model, the Bautista-Manero-Puig (BMP) model, which has been used to reproduce the nonlinear viscoelastic behavior of polymer-like micellar solutions and other complex fluids, is derived. This model predicts rather well steady and unsteady nonlinear features of semi-dilute solutions that exhibit shear-banding flow and the shear-thickening transition observed in dilute surfactant solutions. " 2007.",,,,,,"10.1016/j.jnnfm.2007.02.012",,,"http://hdl.handle.net/20.500.12104/39155","http://www.scopus.com/inward/record.url?eid=2-s2.0-34249699889&partnerID=40&md5=22c9ef4895dbd1cd1dd505ee5dc6d1b6",,,,,,"01-mar",,"Journal of Non-Newtonian Fluid Mechanics",,"22
29",,"146",,"Scopus
WOS",,,,,,"Fluids with internal structure; Irreversible thermodynamics; Non linear viscoelasticity; Rheological equation of state; Shear-banding flow; Shear-thickening transition",,,,,,"A thermodynamic approach to rheology of complex fluids: The generalized BMP model",,"Article" "40968","123456789/35008",,"Rosales-Corral, S., Centro de Investigación Biomédica de Occidente, Instituto Mexicano Del Seguro Social, Sierra Mojada 800 Colonia Independencia, 44340 Guadalajara, JAL, Mexico, Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, United States; Acuna-Castroviejo, D., Institute of Biotechnology, Biomedical Research Center, University of Granada, Avda. del Conocimiento s/n, 18100 Armilla, Granada, Spain; Tan, D.X., Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, United States; López-Armas, G., Centro de Investigación Biomédica de Occidente, Instituto Mexicano Del Seguro Social, Sierra Mojada 800 Colonia Independencia, 44340 Guadalajara, JAL, Mexico; Cruz-Ramos, J., Centro de Investigación Biomédica de Occidente, Instituto Mexicano Del Seguro Social, Sierra Mojada 800 Colonia Independencia, 44340 Guadalajara, JAL, Mexico; Munoz, R., Centro de Ciencias Exactas e Ingenieria, Universidad de Guadalajara, Blvd. Marcelino García Barragán #1421, CP 44100, Guadalajara, JAL, Mexico; Melnikov, V.G., University Center for Biomedical Research Center, University of Av. Universidad #333, Colonia Las Víboras. CP 28040, Colima, Col, Mexico; Manchester, L.C., Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, United States; Reiter, R.J., Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, United States",,"Rosales-Corral, S.
Acuna-Castroviejo, D.
Tan, D.X.
Lopez-Armas, G.
Cruz-Ramos, J.
Munoz, R.
Melnikov, V.G.
Manchester, L.C.
Reiter, R.J.",,"2012",,"Amyloid-beta (A?) pathology is related to mitochondrial dysfunction accompanied by energy reduction and an elevated production of reactive oxygen species (ROS). Monomers and oligomers of A? have been found inside mitochondria where they accumulate in a time-dependent manner as demonstrated in transgenic mice and in Alzheimer's disease (AD) brain. We hypothesize that the internalization of extracellular A? aggregates is the major cause of mitochondrial damage and here we report that following the injection of fibrillar A? into the hippocampus, there is severe axonal damage which is accompanied by the entrance of A? into the cell. Thereafter, A? appears in mitochondria where it is linked to alterations in the ionic gradient across the inner mitochondrial membrane. This effect is accompanied by disruption of subcellular structure, oxidative stress, and a significant reduction in both the respiratory control ratio and in the hydrolytic activity of ATPase. Orally administrated melatonin reduced oxidative stress, improved the mitochondrial respiratory control ratio, and ameliorated the energy imbalance. " 2012 Sergio Rosales-Corral et al.
URI: http://hdl.handle.net/20.500.12104/39189
http://www.scopus.com/inward/record.url?eid=2-s2.0-84862285962&partnerID=40&md5=22c54a7958253a863412efaf0211a6d2
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