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|Title:||A new bilayer chitosan scaffolding as a dural substitute: Experimental evaluation|
|Abstract:||In this paper, a reduced order neural observer (RONO) with a time-varying learning rate is proposed. The proposed scheme is based on a discrete-time recurrent high order neural network (RHONN) trained with an extended Kalman filter (EKF)-based algorithm. A time-varying learning rate is designed in order to improve the learning of the neuronal network in presence of disturbances and parameter variations. This work includes the stability proof of the time-varying learning. The applicability of the developed observer is illustrated via simulations for a nonlinear anaerobic digestion process. " 2014 World Scientific Publishing Company.",,,,,,"10.1142/S0129065714500117",,,"http://hdl.handle.net/20.500.12104/39030","http://www.scopus.com/inward/record.url?eid=2-s2.0-84890705614&partnerID=40&md5=5d55e0e10159d1a1ce2d77eb16f5219f",,,,,,"1",,"International Journal of Neural Systems",,,,"24",,"Scopus|
WOS",,,,,,"Anaerobic digestion process; Extended Kalman filter; Reduced order neural observer; Time-varying learning rate",,,,,,"A neural observer with time-varying learning rate: Analysis and applications",,"Article" "40817","123456789/35008",,,,"Durán Juárez, Juan Manuel",,"2001",,,,,,,,,,"0187-7674","http://hdl.handle.net/20.500.12104/39038",,,"Español",,,,"78",,"Confines de relaciones internacionales y ciencia política",,"sep-18",,"14",,"CLASE",,,,,,,,"Hidrología",,,,"Crisis ambiental en el lago de Chapala y el abastecimiento de agua para Guadalajara",,"journalArticle" "40813","123456789/35008",,"Sandoval-Sánchez, J.H., Department of Neurosurgery, Hospital de Especialidades, Centro Médico Nacional de Occidente, Guadalajara, Jalisco, Mexico; Ramos-Zúñiga, R., Laboratory of Neuroscience, Department of Neuroscience, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Luquín De Anda, S., Laboratory of Neuroscience, Department of Neuroscience, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; López-Dellamary, F., Laboratory of Neuroscience, Department of Neuroscience, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Gonzalez-Castañeda, R., Laboratory of Neuroscience, Department of Neuroscience, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Ramírez-Jaimes, J.D.L.C., Department of Neuropathology, Gomez-Farías Hospital, ISSSTE, Guadalajara, Jalisco, Mexico; Jorge-Espinoza, G., Laboratory of Neuroscience, Department of Neuroscience, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico",,"Sandoval-Sanchez, J.H.
Luquin De Anda, S.
Jorge-Espinoza, G.",,"2012",,"Objective: To evaluate whether bilayer chitosan scaffolding (BChS) can provide a watertight dural closure and permit regeneration by fibroblasts in an experimental in vivo model. Methods: In the in vitro phase, BChS was elaborated and the following characteristics were evaluated: pore size, thickness, water absorption capacity, tensile strength, strain, and toughness. In the second in vivo phase, 27 durectomized New Zealand rabbits were randomly assigned into three duraplasty groups with autologous dura, collagen matrix (CM), or BChS. In all groups, fluid leakage pressure was measured at 10, 21, or 180 days. Histology response to regeneration was evaluated through hematoxylin and eosin stain. Results: BChS was standardized to obtain bilayer scaffoldings with a nonporous layer and a porous layer. The pore size was 10 ?m, total thickness was 400 ?m, strain was 57.8%, and tensile strength was 5.5 gr/mm 2. The physical characteristics of BChS allowed dural closure without cerebrospinal fluid (CSF) leak. There were no differences in fluid leakage pressures between the BChS, dura, and CM groups. Histologic analysis showed fibroblast migration with adequate dural regeneration. Conclusions: BChS is an ideal alternative for a watertight dural closure because it can be sutured, and it induces organized regeneration with fibroblasts without evidence of fibrosis. " 2012 Elsevier Inc. All rights reserved.
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